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Expression and characterization of αvβ5 integrin on intestinal macrophages
Örebro universitet, Institutionen för medicinska vetenskaper. Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland, UK.ORCID-id: 0000-0002-2244-9816
Department of Biological Sciences, Center for Cancer, Genetic Diseases and Gene Regulation, Fordham University, Bronx NY, USA.
Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland, UK.
Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland, UK.
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2018 (Engelska)Ingår i: European Journal of Immunology, ISSN 0014-2980, E-ISSN 1521-4141, Vol. 48, nr 7, s. 1181-1187Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Macrophages play a crucial role in maintaining homeostasis in the intestine, but the underlying mechanisms have not yet been elucidated fully. Here we show for the first time that mature intestinal macrophages in mouse colon and small intestine express high levels of αvβ5 integrin, which acts as a receptor for the uptake of apoptotic cells and can activate molecules involved in several aspects of tissue homeostasis such as angiogenesis and remodelling of the extracellular matrix. αvβ5 is not expressed by other immune cells in the intestine, is already present on intestinal macrophages soon after birth, and its expression is not dependent on the microbiota. In adults, αvβ5 induces the differentiation of monocytes in response to the local environment and it confers intestinal macrophages with the ability to promote engulfment of apoptotic cells via engagement of the bridging molecule milk fat globule EGF-like molecule 8. In the absence of αvβ5, there are fewer monocytes in the mucosa and mature intestinal macrophages have decreased expression of metalloproteases and interleukin 10. Mice lacking αvβ5 on haematopoietic cells show increased susceptibility to chemical colitis and we conclude that αvβ5 contributes to the tissue repair by regulating the homeostatic properties of intestinal macrophages.

Ort, förlag, år, upplaga, sidor
Wiley-VCH Verlagsgesellschaft, 2018. Vol. 48, nr 7, s. 1181-1187
Nyckelord [en]
Homeostasis, Intestine, Macrophage, Phagocytosis, αvβ5 integrin
Nationell ämneskategori
Immunologi
Identifikatorer
URN: urn:nbn:se:oru:diva-66706DOI: 10.1002/eji.201747318ISI: 000437680700010PubMedID: 29676784Scopus ID: 2-s2.0-85049496311OAI: oai:DiVA.org:oru-66706DiVA, id: diva2:1200233
Anmärkning

Funding Agencies:

MRC UK  

Stiftelsen Olle Engkvist Byggmastare, Sweden  2014/27 

National Institutes of Health  R01-EY26215 

Tillgänglig från: 2018-04-23 Skapad: 2018-04-23 Senast uppdaterad: 2018-08-31Bibliografiskt granskad

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Kumawat, Ashok Kumar

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