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Differential effects of dietary fibres on colonic barrier function in elderly individuals with gastrointestinal symptoms
Örebro universitet, Institutionen för medicinska vetenskaper.
Örebro universitet, Institutionen för medicinska vetenskaper.
Örebro universitet, Institutionen för medicinska vetenskaper.ORCID-id: 0000-0002-0362-0008
Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
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(Engelska)Manuskript (preprint) (Övrigt vetenskapligt)
Nationell ämneskategori
Annan medicinsk grundvetenskap
Identifikatorer
URN: urn:nbn:se:oru:diva-66866OAI: oai:DiVA.org:oru-66866DiVA, id: diva2:1203745
Tillgänglig från: 2018-05-04 Skapad: 2018-05-04 Senast uppdaterad: 2018-05-04Bibliografiskt granskad
Ingår i avhandling
1. Non-digestible Polysaccharides and Intestinal Barrier Function: specific focus on its efficacy in elderly and patients with Crohn’s disease
Öppna denna publikation i ny flik eller fönster >>Non-digestible Polysaccharides and Intestinal Barrier Function: specific focus on its efficacy in elderly and patients with Crohn’s disease
2018 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

A large number of elderly suffer from gastrointestinal (GI) symptoms such as constipation and diarrhoea. The underlying mechanisms of age-acquired GI symptoms are not well studied but are necessary to clarify in order to recommend the right treatment. Non-digestible polysaccharides (NPS) are dietary fibres that could have beneficial effects on the intestinal immune system and barrier function, although their efficacy needs to be evaluated. Paper I showed that elderly with GI symptoms have significantly higher small intestinal permeability than a general elderly population, along with a stronger association to psychological distress. In Paper II we performed a randomised controlled trial with a general population of elderly that consumed either placebo, the NPS’s arabinoxylan or oat β-glucan for a period of 6 weeks. No protective effects were observed related to indomethacin-induced intestinal hyperpermeability, inflammatory markers, or self-reported health if compared to placebo. Paper III showed that stimulation with a yeast-derived β-glucan significantly attenuated Compound (C) 48/80-induced hyperpermeability in colonic biopsies from elderly with GI symptoms mounted in Ussing chambers, but not in young healthy adults. Arabinoxylan attenuated only C48/80-induced transcellular permeability in elderly but both paracellular and transcellular permeability in young healthy adults. Paper IV showed that the same yeast-derived β-glucan from paper III could cross the epithelium of ileal tissues from patients with Crohn’s disease (CD) and non-CD controls, mounted in Ussing chambers, and attenuate C48/80-induced hyperpermeability. In conclusion, we found that elderly with GI symptoms display a deteriorated barrier function and that administration of selective NPS can have beneficial effect on intestinal permeability in selective populations.

Ort, förlag, år, upplaga, sidor
Örebro: Örebro University, 2018. s. 121
Serie
Örebro Studies in Medicine, ISSN 1652-4063 ; 180
Nyckelord
Non-digestible polysachharides, beta-glucan, arabinoxylan, barrier function, permeability, Ussing chamber, elderly, Crohn’s disease
Nationell ämneskategori
Annan medicinsk grundvetenskap
Identifikatorer
urn:nbn:se:oru:diva-66055 (URN)978-91-7529-246-5 (ISBN)
Disputation
2018-06-08, Örebro universitet, Campus USÖ, hörsal C3, Södra Grev Rosengatan 32, Örebro, 13:00 (Svenska)
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Handledare
Tillgänglig från: 2018-03-26 Skapad: 2018-03-26 Senast uppdaterad: 2018-05-08Bibliografiskt granskad

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Ganda Mall, John-PeterLöfvendahl, LisaBrummer, Robert JanSchoultz, Ida

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