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Intraoperative high dose rate brachytherapy during breast-conserving surgery: a prospective pilot study
Örebro universitet, Institutionen för medicinska vetenskaper.
Department of surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Department of oncology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Department of oncology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
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(engelsk)Manuskript (preprint) (Annet vitenskapelig)
HSV kategori
Identifikatorer
URN: urn:nbn:se:oru:diva-66949OAI: oai:DiVA.org:oru-66949DiVA, id: diva2:1205890
Tilgjengelig fra: 2018-05-15 Laget: 2018-05-15 Sist oppdatert: 2018-05-18bibliografisk kontrollert
Inngår i avhandling
1. Adjuvant treatments to prevent local reurrence after breast-conserving surgery for early breast cancer: radiation, endocrine- or brachytherapy
Åpne denne publikasjonen i ny fane eller vindu >>Adjuvant treatments to prevent local reurrence after breast-conserving surgery for early breast cancer: radiation, endocrine- or brachytherapy
2018 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Radiotherapy after breast-conserving surgery due to breast cancer is an established treatment, known to reduce the incidence of recurrence and even death from the disease. However some women are over-treated with sometimes serious adverse effects. De-escalating the treatment and find alternative adjuvant methods are becoming an important issue. In study I, we present the outcomes from a long-term follow-up trial randomising 381 women with breast cancer to surgery alone or to surgery with the addition of radiotherapy. The incidence of any first breast cancer event was significantly higher without radiotherapy but the protecting effect lasted for only the first five years. In study II, we collected the tissue samples from the tumours in study I to construct tissue micro-arrays. Immuno-histochemical analyses were performed and the tumours were classified into the intrinsic subtypes. The luminal B/HER2 negative subtype was found to be prognostic for ipsilateral breast cancer recurrence (IBTR). The intrinsic subtypes did not interact with radiotherapy. Study III was a multicentre prospective cohort study where the 601 study participants with early breast cancer were treated with surgery and endocrine therapy alone without postoperative radiotherapy. The cumulative incidence of IBTR after five years was low -1.2% and only one woman died of breast cancer. In study IV we evaluated the feasibility and treatment complications when introducing a new method for intraoperative brachytherapy (IOBT) using HDR equipment. We designed a pilot study including fifty women where half of them were treated during primary surgery and the others during a second procedure. The treatment was well tolerated and no logistic problems were reported. No acute adverse effects from IOBT were seen.

sted, utgiver, år, opplag, sider
Örebro: Örebro University, 2018. s. 65
Serie
Örebro Studies in Medicine, ISSN 1652-4063 ; 181
Emneord
Breast-conserving surgery, radiotherapy, endocrine therapy, intraoperative brachytherapy
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-66057 (URN)978-91-7529-266-3 (ISBN)
Disputas
2018-06-08, Örebro universitet, Campus USÖ, hörsal C1, Södra Grev Rosengatan 32, Örebro, 09:00 (svensk)
Opponent
Veileder
Tilgjengelig fra: 2018-03-26 Laget: 2018-03-26 Sist oppdatert: 2018-10-03bibliografisk kontrollert

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