oru.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Comparison between professional sampling and self-sampling for HPV-based cervical cancer screening among postmenopausal women
Örebro universitet, Institutionen för hälsovetenskaper. Department of Women’s Health, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden.
Örebro universitet, Institutionen för medicinska vetenskaper. Department of Laboratory Medicine, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden.
Örebro universitet, Institutionen för hälsovetenskaper. Department of Laboratory Medicine, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden.ORCID-id: 0000-0001-9992-266x
Örebro universitet, Institutionen för medicinska vetenskaper. Department of Laboratory Medicine, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden.ORCID-id: 0000-0001-6881-237X
Visa övriga samt affilieringar
2018 (Engelska)Ingår i: International Journal of Gynecology & Obstetrics, ISSN 0020-7292, E-ISSN 1879-3479, Vol. 142, nr 3, s. 359-364Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

OBJECTIVE: To investigate whether self-sampling is as reliable as professional sampling for HPV testing and genotype detection among postmenopausal women.

METHODS: In the present prospective cross-sectional study, women in Örebro County, Sweden, who had high-risk HPV (hrHPV) and normal cytology results in exit screening tests conducted in between January 1, 2012, and December 31, 2014, were invited to follow-up screenings between February 24, 2015 and May 15, 2015, that included professional sampling and self-sampling. HPV genotypes were identified by a DNA-based assay that could detect 35 HPV genotypes. Findings between the different sampling methods were compared.

RESULTS: Of 143 women who participated, 119 returned a self-sample. Completely concordant results were observed in 67 of these samples when both hrHPV and low-risk HPV genotypes were analyzed. Overall, 99 (83.2%) women had the same clinically relevant finding from both sampling methods. Twenty women had discordant hrHPV results (hrHPV detected in 10 self-samples vs 10 professionally collected samples; Cohen κ 0.66, 95% confidence interval 0.53-0.80). There was no significant difference between the two sampling methods for clinically significant infections (P>0.99) or extended genotyping (P=0.827).

CONCLUSION: Postmenopausal women could be offered self-sampling devices to increase screening-program coverage while maintaining test quality.

Ort, förlag, år, upplaga, sidor
Wiley-Blackwell Publishing Inc., 2018. Vol. 142, nr 3, s. 359-364
Nyckelord [en]
Cervical cancer, HPV, Postmenopausal women, Professional sampling, Screening, Self-sample
Nationell ämneskategori
Cancer och onkologi Reproduktionsmedicin och gynekologi
Identifikatorer
URN: urn:nbn:se:oru:diva-67134DOI: 10.1002/ijgo.12538ISI: 000440652000017PubMedID: 29856071Scopus ID: 2-s2.0-85051073715OAI: oai:DiVA.org:oru-67134DiVA, id: diva2:1213223
Anmärkning

Funding Agencies:

Region Örebro County Research Committee  

Örebro University Hospital Research Foundation  

BBMRI.se

Tillgänglig från: 2018-06-04 Skapad: 2018-06-04 Senast uppdaterad: 2018-08-30Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMedScopus

Personposter BETA

Bergengren, LovisaKaliff, MalinLillsunde-Larsson, GabriellaKarlsson, MatsHelenius, Gisela

Sök vidare i DiVA

Av författaren/redaktören
Bergengren, LovisaKaliff, MalinLillsunde-Larsson, GabriellaKarlsson, MatsHelenius, Gisela
Av organisationen
Institutionen för hälsovetenskaperInstitutionen för medicinska vetenskaper
I samma tidskrift
International Journal of Gynecology & Obstetrics
Cancer och onkologiReproduktionsmedicin och gynekologi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 254 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf