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Effect of Vitamin D supplementation on body composition and cardiorespiratory fitness in overweight men: a randomized controlled trial
Department of Endocrinology, School of Medical Sciences, Örebro University, Örebro, Sweden.
Örebro universitet, Institutionen för medicinska vetenskaper. Department of Pediatrics.ORCID-id: 0000-0002-1440-9961
School of Medical Sciences, Örebro University, Örebro, Sweden.
School of Medical Sciences, Örebro University, Örebro, Sweden.
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2018 (Engelska)Ingår i: Endocrine (Basingstoke), ISSN 1355-008X, E-ISSN 1559-0100, Vol. 61, nr 3, s. 388-397Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Purpose: Several observational studies have shown an association between vitamin D deficiency and non-skeletal major health issues including impaired cardiorespiratory fitness and adiposity. Only a few studies have examined the impact of vitamin D supplementation on these conditions and the results are ambiguous. The aim of this study was to examine the effect of vitamin D supplementation on body composition and cardiorespiratory fitness in overweight/obese men with vitamin D deficiency.

Methods: This study was a prospective, placebo controlled, double blinded, randomized trial with a study period of 6 months. Forty overweight/obese men (BMI > 25 kg/m2) with vitamin D deficiency (25(OH)D ≤ 55 nmol/L) were randomized to receive either 2000 IU Cholecalciferol drops or the equivalent amount of drops of placebo. At baseline and follow up body composition and cardiorespiratory fitness were measured and blood samples were obtained. Body composition was measured using bioelectrical impedance analysis (BIA) and cardiorespiratory fitness using cardiopulmonary exercise test (CPET). The primary outcomes were changes in percentage body fat and in maximum oxygen uptake (VO2max).

Results: No statistically significant difference between the placebo and the intervention group regarding changes in percentage body fat (p = 0.54) and VO2max (p = 0.90) was observed. Moreover, there was no statistically significant difference between the groups concerning changes in BMI (p = 0.26), maximum load (p = 0.89) and oxygen uptake at anaerobic threshold (AT) (p = 0.14).

Conclusions: We conclude that treatment with 2000 IU/d vitamin D for 6 months does not impact body composition or maximum oxygen uptake in overweight/obese men with vitamin D deficiency.

Ort, förlag, år, upplaga, sidor
Humana Press, 2018. Vol. 61, nr 3, s. 388-397
Nyckelord [en]
Bioelectrical impedance analysis, Body composition, Cardiopulmonary exercise test, Cardiorespiratory fitness, Vitamin D
Nationell ämneskategori
Näringslära Endokrinologi och diabetes
Identifikatorer
URN: urn:nbn:se:oru:diva-68368DOI: 10.1007/s12020-018-1665-6ISI: 000442234600005PubMedID: 29978375Scopus ID: 2-s2.0-85049582617OAI: oai:DiVA.org:oru-68368DiVA, id: diva2:1238468
Anmärkning

Funding Agencies:

Nyckelfonden OLL-404451

Örebro University ALF 2016:1 OLL-615521

Tillgänglig från: 2018-08-13 Skapad: 2018-08-13 Senast uppdaterad: 2019-03-26Bibliografiskt granskad

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Särnblad, StefanRask, EvaRask, Peter

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Institutionen för medicinska vetenskaperRegion Örebro län
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Endocrine (Basingstoke)
NäringsläraEndokrinologi och diabetes

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