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Related carbapenemase-producing Klebsiella isolates detected in both a hospital and associated aquatic environment in Sweden
Örebro University, School of Science and Technology. (The Life Science Centre - Biology)
Örebro University, School of Health Sciences. Örebro University Hospital.
Abbott (Alere Technologies GmbH), Jena, Germany; InfectoGnostics Research Campus, Jena, Germany; Research Alliance - Leibniz Health Technologies, Leibniz Institute of Photonic Technology, Jena, Germany.
Örebro University, School of Medical Sciences.ORCID iD: 0000-0001-5939-2932
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2018 (English)In: European Journal of Clinical Microbiology and Infectious Diseases, ISSN 0934-9723, E-ISSN 1435-4373, Vol. 37, no 12, p. 2241-2251Article in journal (Refereed) Published
Abstract [en]

Carbapenem antibiotics are one of the last-resort agents against multidrug-resistant (MDR) bacteria. The occurrence of carbapenemase-producing Enterobacteriaceae (CPE) in wastewater and aquatic environments is an indication of MDR bacteria in the community. This study evaluated CPE in aquatic environments and compared them to the local hospital isolates in Sweden. Phenotypic and genotypic analyses of antibiotic resistance of environmental and clinical CPE were performed. The relatedness of the isolates and possible clonal dissemination was evaluated using phylogenetic and phyloproteomic analysis. Klebsiella oxytoca carrying carbapenemase genes (blaVIM-1, blaIMP-29) were isolated from wastewater and the recipient river, while K. oxytoca (blaVIM-1) and Klebsiella pneumoniae (blaVIM-1, blaOXA-48, blaNDM-1, blaKPC-3) were isolated from patients at the local clinics or hospital. The K. oxytoca classified as sequence type 172 (ST172) isolated from the river was genotypically related to two clinical isolates recovered from patients. The similarity between environmental and clinical isolates suggests the dispersion of blaVIM-1 producing K. oxytoca ST172 from hospital to aquatic environment and the likelihood of its presence in the community. This is the first report of CPE in aquatic environments in Sweden; therefore, surveillance of aquatic and hospital environments for CPE in other urban areas is important to determine the major transfer routes in order to formulate strategies to prevent the spread of MDR bacteria.

Place, publisher, year, edition, pages
Springer, 2018. Vol. 37, no 12, p. 2241-2251
Keywords [en]
Antimicrobial resistance, Carbapenemase-producing Enterobacteriaceae, Extended spectrum beta-lactamase, Klebsiella oxytoca, Klebsiella pneumoniae, Multidrug resistance
National Category
Infectious Medicine Microbiology in the medical area
Identifiers
URN: urn:nbn:se:oru:diva-68676DOI: 10.1007/s10096-018-3365-9ISI: 000449921100003PubMedID: 30171482Scopus ID: 2-s2.0-85053311566OAI: oai:DiVA.org:oru-68676DiVA, id: diva2:1244590
Funder
Swedish Research Council Formas, 219-2014-837
Note

Funding Agency:

Nyckelfonden at Orebro University Hospital 

Available from: 2018-09-03 Created: 2018-09-03 Last updated: 2018-11-29Bibliographically approved

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Khan, Faisal AhmadHellmark, BengtSöderquist, BoJass, Jana

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Khan, Faisal AhmadHellmark, BengtSöderquist, BoJass, Jana
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European Journal of Clinical Microbiology and Infectious Diseases
Infectious MedicineMicrobiology in the medical area

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CiteExportLink to record
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