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MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines
Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore.
Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Cellular and Molecular Epigenetics Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan; Division of Physiological Chemistry and Metabolism, Keio University Faculty of Pharmacy, Tokyo, Japan.
National Institute of Genetics, Shizuoka, Japan and RIKEN Center for Sustainable Resource Science, Yokohama, Japan.
Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore.
Show others and affiliations
2018 (English)In: Journal of Lipid Research, ISSN 0022-2275, E-ISSN 1539-7262, Vol. 59, no 10, p. 2001-2017Article in journal (Refereed) Published
Abstract [en]

Human blood is a self-regenerating lipid-rich biological fluid that is routinely collected in hospital settings. The inventory of lipid molecules found in blood plasma (plasma lipidome) offers insights into individual metabolism and physiology in health and disease. Disturbances in the plasma lipidome also occur in conditions that are not directly linked to lipid metabolism; therefore, plasma lipidomics based on MS is an emerging tool in an array of clinical diagnostics and disease management. However, challenges exist in the translation of such lipidomic data to clinical applications. These relate to the reproducibility, accuracy, and precision of lipid quantitation, study design, sample handling, and data sharing. This position paper emerged from a workshop that initiated a community-led process to elaborate and define a set of generally accepted guidelines for quantitative MS-based lipidomics of blood plasma or serum, with harmonization of data acquired on different instrumentation platforms across independent laboratories as an ultimate goal. We hope that other fields may benefit from and follow such a precedent.

Place, publisher, year, edition, pages
American Society for Biochemistry and Molecular Biology, 2018. Vol. 59, no 10, p. 2001-2017
Keywords [en]
National Institute of Standards and Technology Standard Reference Material 1950, absolute concentrations, clinical research, clinical trials, data sharing, diagnostic tools, lipids, mass spectrometry, quality control
National Category
Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:oru:diva-69218DOI: 10.1194/jlr.S087163ISI: 000445444500018PubMedID: 30115755Scopus ID: 2-s2.0-85054072331OAI: oai:DiVA.org:oru-69218DiVA, id: diva2:1253182
Funder
Swedish Heart Lung Foundation, 20170734 20170603Swedish Research Council
Note

Funding Agencies:

National University of Singapore via the Life Sciences Institute  

National Research Foundation Singapore Grant  NRFI2015-05 

Deutsche Forschungsgemeinschaft  TRR83 

LiSyM Consortium - Bundesministerium fur Bildung und Forschung, Germany  

Foundation for the National Institutes of Health  U54 GM069338  RO1 GM20501-41 

Japan Agency for Medical Research and Development Grant  JP18gm5910001 

National Health and Medical Research Council of Australia  

Japan Society for the Promotion of Science  15H05897  15H05898  17H03621 

Japan Agency for Medical Research and Development Grants  17gm0910005h0403  17gm1010006h0001 

National Bioscience Database Center Togo Project, Japan  

Biotechnology and Biological Sciences Research Council Grant  BB/P013384/1 

Medical Research Council Grant  MR/M004821/1 

Academy of Finland Grant  292568 

European Commission Project LITMUS Grant  777377 

National Institute of General Medical Sciences Grant  R01 GM105724 

Available from: 2018-10-04 Created: 2018-10-04 Last updated: 2018-10-10Bibliographically approved

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