oru.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Osteoporotic Fractures in Childhood Cancer Survivors - ALICCS Cohort Study
Karolinska Institutet, Department of Women's and Children's Health, Stockholm, Sweden.
Danish Cancer Society Research Centre, Survivorship Unit, Copenhagen, Denmark.
Karolinska Institutet, Department of Women's and Children's Health, Stockholm, Sweden; Uppsala University, Department of Women's and Children's Health, Uppsala, Sweden.
Örebro universitet, Institutionen för medicinska vetenskaper. Region Örebro län. Karolinska Institutet, Clinical Epidemiology Unit, Stockholm, Sweden; University College London, Department of Epidemiology and Public Health, London, United Kingdom; Örebro University, Clinical Epidemiology and Biostatistics‐ Faculty of Medicine and Health, Örebro, Sweden.ORCID-id: 0000-0001-6328-5494
Visa övriga samt affilieringar
2018 (Engelska)Ingår i: Pediatric Blood & Cancer, ISSN 1545-5009, E-ISSN 1545-5017, Vol. 65, nr Suppl.2, s. S693-S694Artikel i tidskrift, Meeting abstract (Övrigt vetenskapligt) Published
Abstract [en]

Background/Objectives: Children and adolescents undergoing treatment for cancer are exposed to multiple factors that impact the development of peak bone mass and bone quality. The aims of this study were to examine the risks and cumulative incidence of osteoporotic fractures in childhood cancer survivors and identify subgroups at higher risk.

Design/Methods: In the national cancer registries of Denmark, Finland, Iceland and Sweden we identified patients diagnosed with cancer before 20 years of age from the start of registration in the 1940s and 1950s through 2008. We compared 26.334 one‐year survivors with a cohort of 162.372 age‐ and sex‐matched population comparison subjects selected from the national population registries. With data derived from national hospital registries we estimated the standardized hospitalization rate ratios (SHRR) and the mean cumulative count (MCC) of hospital admissions for osteoporotic fractures. To identify subgroups at risk we used Cox regression models to generate hazard ratios (HR) for osteoporotic fractures. Death and new cancer were treated as competing risks.

Results: The estimated SHRR for the first osteoporotic fracture was 1.41 (95% CI; 1.27‐1.58) but the MCC for recurrent osteoporotic fractures did not differ between the survivors and the comparison group. The SHRR for isolated hip fractures was 2.90 (2.32‐3.63). The adjusted HR for osteoporotic fracture as the first event was 1.53 (1.09‐2.16) if cancer was diagnosed 15‐19 years and 2.10 (1.48‐2.98) for long‐term survivors of CNS tumors. Survivors 15‐19 years at cancer diagnosis and long‐term survivors of CNS tumors were also at higher risk of experiencing a second fracture, HR 3.29 (1.65‐6.55) and HR 2.71 (1.45‐5.05), respectively.

Conclusions: Childhood cancer survivors are at higher risk of being hospitalized for osteoporotic fractures but the burden of recurrent fractures is not higher. For subgroups at risk, surveillance of bone health and measures to increase bone strength and prevent fractures should be encouraged.

Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2018. Vol. 65, nr Suppl.2, s. S693-S694
Nationell ämneskategori
Cancer och onkologi Hematologi Pediatrik
Identifikatorer
URN: urn:nbn:se:oru:diva-69469ISI: 000445195005328OAI: oai:DiVA.org:oru-69469DiVA, id: diva2:1254821
Tillgänglig från: 2018-10-10 Skapad: 2018-10-10 Senast uppdaterad: 2018-10-10Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Personposter BETA

Montgomery, Scott

Sök vidare i DiVA

Av författaren/redaktören
Montgomery, Scott
Av organisationen
Institutionen för medicinska vetenskaperRegion Örebro län
I samma tidskrift
Pediatric Blood & Cancer
Cancer och onkologiHematologiPediatrik

Sök vidare utanför DiVA

GoogleGoogle Scholar

urn-nbn

Altmetricpoäng

urn-nbn
Totalt: 171 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf