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ADHD-originating in the gut?: The emergence of a new explanatory model
School of Medical Sciences, Örebro University, Örebro, Sweden.
Örebro University, School of Medical Sciences.ORCID iD: 0000-0002-0362-0008
2018 (English)In: Medical Hypotheses, ISSN 0306-9877, E-ISSN 1532-2777, Vol. 120, p. 135-145Article in journal (Refereed) Published
Abstract [en]

The microbiome-gut-brain axis paradigm explains that alterations in the central nervous system and behavior may be secondary to functional changes in the gut in general and more specifically the enteric nervous system. An unfavorable development of the intestinal microbial ecosystem, leading to e.g. a diminished microbial diversity, may play a central role. This paper outlines, and describes the theoretical basis of, a novel integrative model explaining the etiology and pathogenesis of ADHD in a microbiota-gut-brain context, taking into account the complexity of the bi-directional signaling between the gut and the brain.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 120, p. 135-145
Keywords [en]
ADHD, Enteric nervous system, Autonomic nervous system, Microbiome-gut-brain axis, Explanatory model
National Category
Neurology
Identifiers
URN: urn:nbn:se:oru:diva-69969DOI: 10.1016/j.mehy.2018.08.022ISI: 000447100300024PubMedID: 30220333OAI: oai:DiVA.org:oru-69969DiVA, id: diva2:1260133
Available from: 2018-11-01 Created: 2018-11-01 Last updated: 2019-02-11Bibliographically approved

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Brummer, Robert Jan

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