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Individual variations in platelet reactivity towards ADP, epinephrine, collagen and nitric oxide, and the association to arterial function in young, healthy adults
Örebro University, School of Medical Sciences. (Cardiovascular Research Centre (CVRC))
Örebro University, School of Medical Sciences. (Cardiovascular Research Centre (CVRC))
Örebro University, School of Medical Sciences. (Cardiovascular Research Centre (CVRC))ORCID iD: 0000-0003-4253-3369
Örebro University, School of Medical Sciences. (Cardiovascular Research Centre (CVRC))ORCID iD: 0000-0003-2519-203X
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2019 (English)In: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 174, p. 5-12Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: Platelet aggregation and secretion can be induced by a large number of endogenous activators, such as collagen, adenosine diphosphate (ADP) and epinephrine. Conversely, the blood vessel endothelium constitutively release platelet inhibitors including nitric oxide (NO) and prostacyclin. NO and prostacyclin are also well-known vasodilators and contribute to alterations in local blood flow and systemic blood pressure.

MATERIALS AND METHODS: In this study we investigated individual variations in platelet reactivity and arterial functions including blood pressure and flow-mediated vasodilation (FMD) in 43 young, healthy individuals participating in the Lifestyle, Biomarkers and Atherosclerosis (LBA) study. Platelet aggregation and dense granule secretion were measured simultaneously by light transmission and luminescence. FMD was measured with ultrasound.

RESULTS: The platelet function assay showed inter-individual differences in platelet reactivity. Specifically, a sub-group of individuals had platelets with an increased response to low concentrations of ADP and epinephrine, but not collagen. When the NO-donor S-nitroso-N-acetyl-DL-penicillamine (SNAP) was combined with high doses of these platelet activators, the results indicated for sub-groups of NO-sensitive and NO-insensitive platelets. The individuals with NO-sensitive platelets in response to SNAP in combination with collagen had a higher capacity of FMD of the arteria brachialis.

CONCLUSIONS: Platelet reactivity towards ADP, epinephrine and NO differs between young, healthy individuals. Some individuals have a more effective response towards NO, both in the aspect of platelet inhibition ex vivo, as well as vasodilation in vivo.

Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 174, p. 5-12
Keywords [en]
Adenosine diphosphate, Collagen, Epinephrine, Nitric oxide, Platelet activation, Vasodilation
National Category
Physiology Hematology Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:oru:diva-70787DOI: 10.1016/j.thromres.2018.12.008ISI: 000456949100002PubMedID: 30543988Scopus ID: 2-s2.0-85058021347OAI: oai:DiVA.org:oru-70787DiVA, id: diva2:1271996
Funder
AFA Insurance, 130275Knowledge FoundationAvailable from: 2018-12-18 Created: 2018-12-18 Last updated: 2019-03-26Bibliographically approved

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Lindkvist, MadeleneFernberg, UlrikaLjungberg, LizaFälker, KnutFernström, MariaHurtig-Wennlöf, AnitaGrenegård, Magnus

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Thrombosis Research
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