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Lysophosphatidic Acid Signaling in Obesity and Insulin Resistance
Örebro University, School of Medical Sciences. Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Dalhousie Medicine New Brunswick, Saint John, Canada. (Cardiovascular research center)ORCID iD: 0000-0002-4589-6440
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Dalhousie Medicine New Brunswick, Saint John, Canada.
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Dalhousie Medicine New Brunswick, Saint John, Canada.
2018 (English)In: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 10, no 4, article id 399Article, review/survey (Refereed) Published
Abstract [en]

Although simple in structure, lysophosphatidic acid (LPA) is a potent bioactive lipid that profoundly influences cellular signaling and function upon binding to G protein-coupled receptors (LPA1-6). The majority of circulating LPA is produced by the secreted enzyme autotaxin (ATX). Alterations in LPA signaling, in conjunction with changes in autotaxin (ATX) expression and activity, have been implicated in metabolic and inflammatory disorders including obesity, insulin resistance, and cardiovascular disease. This review summarizes our current understanding of the sources and metabolism of LPA with focus on the influence of diet on circulating LPA. Furthermore, we explore how the ATX-LPA pathway impacts obesity and obesity-associated disorders, including impaired glucose homeostasis, insulin resistance, and cardiovascular disease.

Place, publisher, year, edition, pages
MDPI, 2018. Vol. 10, no 4, article id 399
Keywords [en]
Lipidology, atherosclerosis
National Category
Medical and Health Sciences Endocrinology and Diabetes
Research subject
Health and Medical Care Research
Identifiers
URN: urn:nbn:se:oru:diva-71322DOI: 10.3390/nu10040399ISI: 000435182900015PubMedID: 29570618Scopus ID: 2-s2.0-85044606125OAI: oai:DiVA.org:oru-71322DiVA, id: diva2:1277358
Note

Funding Agencies:

Natural Sciences and Engineering Research Council of Canada (NSERC)

New Brunswick Health Research Foundation (NBHRF) 

Heart and Stroke Foundation of New Brunswick

Available from: 2019-01-10 Created: 2019-01-10 Last updated: 2019-01-10Bibliographically approved

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Paramel Varghese, Geena

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