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Findings of multiple HPV genotypes in cervical carcinoma are associated with poor cancer-specific survival in a Swedish cohort of cervical cancer primarily treated with radiotherapy
Örebro University, School of Medical Sciences. Department of Laboratory Medicine.
Department of Oncology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Department of Oncology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Örebro University, School of Medical Sciences. Department of Laboratory Medicine.ORCID iD: 0000-0003-2317-5738
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2018 (English)In: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol. 9, no 27, p. 18786-18796Article in journal (Refereed) Published
Abstract [en]

Cervical cancer (CC) is one of the most common cancers in women and virtually all cases of CC are a result of a persistent infection of human papillomavirus (HPV). For disease detected in early stages there is curing treatment but when diagnosed late with recurring disease and metastasis there are limited possibilities. Here we evaluate HPV impact on treatment resistance and metastatic disease progression. Prevalence and distribution of HPV genotypes and HPV16 variants in a Swedish CC patient cohort (n=209) was evaluated, as well as HPV influence on patient prognosis. Tumor samples suitable for analysis (n=204) were genotyped using two different real-time PCR methods. HPV16 variant analysis was made using pyrosequencing. Results showed that HPV prevalence in the total series was 93%. Of the HPV-positive samples, 13% contained multiple infections, typically with two high-risk HPV together. Primary cure rate for the complete series was 95%. Recurrence rate of the complete series was 28% and distant recurrences were most frequent (20%). Patients with tumors containing multiple HPV-strains and particularly HPV genotypes belonging to the alpha 7 and 9 species together had a significantly higher rate of distant tumor recurrences and worse cancer-specific survival rate.

Place, publisher, year, edition, pages
Impact Journals LLC , 2018. Vol. 9, no 27, p. 18786-18796
Keywords [en]
HPV, cervical cancer, recurrences, survival
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:oru:diva-71672DOI: 10.18632/oncotarget.24666PubMedID: 29721161Scopus ID: 2-s2.0-85045206587OAI: oai:DiVA.org:oru-71672DiVA, id: diva2:1281568
Available from: 2019-01-22 Created: 2019-01-22 Last updated: 2019-01-24Bibliographically approved

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Kaliff, MalinHelenius, GiselaKarlsson, Mats G.Lillsunde-Larsson, Gabriella

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