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Body mass index in early pregnancy and future risk of severe liver disease: a population-based cohort study
Department of Upper GI, Unit of Hepatology, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Unit of Biostatistics, Institute of Environmental Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Stress Research Institute, Stockholm University, Stockholm, Sweden.
Unit of Biostatistics, Institute of Environmental Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
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2019 (English)In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 49, no 6, p. 789-796Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: In young men, high body mass index (BMI) has been linked to liver disease later in life, but it is unclear if this also applies to women.

AIM: To study the association between BMI early in life and development of liver disease later in life in women.

METHODS: We obtained data on early pregnancy BMI from 1 139 458 Swedish women between 1992 and 2015. National registers were used to ascertain incident severe liver disease, defined as cirrhosis, decompensated liver disease (hepatocellular carcinoma, oesophageal varices, hepatorenal syndrome or hepatic encephalopathy) or liver failure. A Cox regression model was used to investigate associations of BMI with incident severe liver disease adjusting for maternal age, calendar year, country of birth, smoking, civil status and education.

RESULTS: (95% CI 1.02-1.05). A diagnosis of diabetes was associated with an increased risk of severe liver disease independent of baseline BMI.

CONCLUSION: A high BMI early in life in women is associated with a dose-dependent, increased risk for future severe liver disease.

Place, publisher, year, edition, pages
Blackwell Science Ltd. , 2019. Vol. 49, no 6, p. 789-796
National Category
Public Health, Global Health, Social Medicine and Epidemiology Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:oru:diva-72885DOI: 10.1111/apt.15162ISI: 000459827800015PubMedID: 30714185Scopus ID: 2-s2.0-85060992724OAI: oai:DiVA.org:oru-72885DiVA, id: diva2:1293225
Note

Funding Agencies:

Stockholm County (Clinical Postdoctorial Appointment)  

Bengt Ihre Fellowship 

Available from: 2019-03-04 Created: 2019-03-04 Last updated: 2019-06-19Bibliographically approved

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Ludvigsson, Jonas F.

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