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Long-term follow-up in patients treated with electrochemotherapy for non-melanoma skin cancer in the head and neck area
Department of Otolaryngology, Örebro Universitet Institutionen for Medicinska Vetenskaper, Örebro University Hospital, Örebro, Sweden.
Department of Otolaryngology, Örebro Universitet Institutionen for Medicinska Vetenskaper, Örebro University Hospital, Örebro, Sweden.
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Otolaryngology.
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Otolaryngology.
2019 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 139, no 2, p. 195-200Article in journal (Refereed) Published
Abstract [en]

Background: Electrochemotherapy (ECT) is a cancer treatment modality where the intracellular accumulation of chemotherapeutic agents is enhanced by an applied electrical field.

Aims/Objectives: To evaluate the long-term efficacy, safety and functional outcome after ECT treatment in high-risk non-melanoma skin cancer (NMSC) with curative intent.

Materials and methods: Seven patients with SCC or BCC in the head and neck area were treated with ECT with intratumoral bleomycin administration.

Results: Five patients were cured by ECT as a mono-modality treatment after a median 10-year follow-up period. Two patients had recurrences and/or persisting tumors after treatment that required salvage surgery and radiotherapy. In two patients, the eye was spared with no visual impairment. In another patient, full facial nerve function was spared.

Conclusions: ECT can be a curative as well as an organ and function-sparing mono modality treatment in high-risk NMSC.

Place, publisher, year, edition, pages
Taylor & Francis Group, 2019. Vol. 139, no 2, p. 195-200
Keywords [en]
Electrochemotherapy, non-melanoma skin cancer, squamous cell carcinoma, basal cell carcinoma
National Category
Otorhinolaryngology
Identifiers
URN: urn:nbn:se:oru:diva-73500DOI: 10.1080/00016489.2018.1543950ISI: 000461648000014PubMedID: 30734631Scopus ID: 2-s2.0-85061282989OAI: oai:DiVA.org:oru-73500DiVA, id: diva2:1302313
Note

Funding Agency:

Örebro County Council

Available from: 2019-04-04 Created: 2019-04-04 Last updated: 2019-04-04Bibliographically approved

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Von Beckerath, MathiasLandström, Fredrik

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