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Circulating inflammation markers and prostate cancer
Örebro universitet, Institutionen för medicinska vetenskaper. Department of Urology.
Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, United States.
Örebro universitet, Institutionen för medicinska vetenskaper. Region Örebro län. Department of Urology.ORCID-id: 0000-0001-5533-7899
Department of Medical Oncology, Dana–Farber Cancer Institute, Boston, United States.
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(engelsk)Manuskript (preprint) (Annet vitenskapelig)
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Identifikatorer
URN: urn:nbn:se:oru:diva-73573OAI: oai:DiVA.org:oru-73573DiVA, id: diva2:1302937
Tilgjengelig fra: 2019-04-08 Laget: 2019-04-08 Sist oppdatert: 2019-04-08bibliografisk kontrollert
Inngår i avhandling
1. Inflammation and prostate carcinogenesis: influence of immune characteristics and early-adulthood exposure to inflammatory conditions on prostate cancer risk
Åpne denne publikasjonen i ny fane eller vindu >>Inflammation and prostate carcinogenesis: influence of immune characteristics and early-adulthood exposure to inflammatory conditions on prostate cancer risk
2019 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Chronic inflammation has been implicated in the development of several types of cancer, and evidence from observational and animal studies suggests that it may play a role also in prostate carcinogenesis. Recent observations have brought Cutibacterium acnes (C. acnes) forward as a possible causative agent in pro-oncogenic prostatic inflammation. However, evidence also suggest that underlying immune characteristics contribute to prostate cancer risk. The overall aim of this thesis was to explore potential mechanisms underlying the proposed link between inflammation and prostate cancer, by evaluating associations between inflammatory conditions during early adulthood, circulating inflammation markers, and prostate cancer. Due to the suggested role of C. acnes in both diseases, we aimed to investigate whether acne vulgaris is a determinant of prostate cancer. Using prospectively collected data from Swedish national registers, we observed that presence of acne during early adulthood conferred an increased risk of prostate cancer later in life. Similarly, we found that appendicitis before late adolescence – a proposed marker of individual immune characteristics – to be positively associated with subsequent prostate cancer. We further evaluated whether prostatic C. acnes infection is linked with elevated systemic levels of IL6 and CXCL8, two inflammation markers previously associated with prostate cancer. No association was observed, however, potentially explained by the subclinical low-grade infection typically caused by C. acnes. Finally, we evaluated 52 circulating inflammation markers as determinants for prostate cancer in a population-based case-control study. In this hypothesis-generating study, we identified CX3CL1, CCL21, PDGF-BB, CCL11 and IL10 as candidate markers for evaluation in prospective studies. If confirmed, these markers may hint at targetable molecular pathways involved in prostate carcinogenesis.

sted, utgiver, år, opplag, sider
Örebro: Örebro University, 2019. s. 100
Serie
Örebro Studies in Medicine, ISSN 1652-4063 ; 191
Emneord
Prostate cancer, inflammation, Cutibacterium acnes, acne, appendicitis, cytokines, circulating, inflammation marker, IL6, CXCL8
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Identifikatorer
urn:nbn:se:oru:diva-72812 (URN)978-91-7529-280-9 (ISBN)
Disputas
2019-05-10, Örebro universitet, Campus USÖ, hörsal C1, Södra Grev Rosengatan 32, Örebro, 12:30 (svensk)
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Veileder
Tilgjengelig fra: 2019-02-27 Laget: 2019-02-27 Sist oppdatert: 2019-04-10bibliografisk kontrollert

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