oru.sePublikasjoner
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Recent Advancements in Bipolar Disorder studies through Genomic, Epigenomic and Metagenomic Approaches
e-NIOS Applications PC, Kallithea, Greece; Laboratory of Biotechnology, School of Chemical Engineering, National Technical University of Athens, Athens, Greece.
e-NIOS Applications PC, Kallithea, Greece; Metabolic Engineering and Bioinformatics Group, Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, Athens, Greece.
Örebro universitet, Institutionen för medicinska vetenskaper. (NGBI, Experimentell neuropsykiatri)ORCID-id: 0000-0001-8102-1804
Laboratory of Biotechnology, School of Chemical Engineering, National Technical University of Athens, Athens, Greece.
2019 (engelsk)Inngår i: Journal of Psychiatry and Psychology Research, ISSN 2640-6136, Vol. 2, nr 1, s. 56-66Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Bipolar disorder is a complex and highly heritable psychiatric disorder characterized by severe mood alterations. The precise geneticunderpinnings of the disease have not been identified so far, despite numerous genome-wide association findings. This review describes thecurrent state of genetic studies based on next generation sequencing technologies including whole exome and whole genome sequencing, aswell as RNA-sequencing and highlights the fact that the integration of these studies can reveal novel knowledge such as the functional roleof gene variants. However, due to the complexity of bipolar disorder, it is a compelling candidate for studies beyond DNA and RNAsequencing. Epigenetic alterations, defined as heritable but reversible modifications including DNA methylation, DNAhydroxymethylation, histone modifications and non-coding RNAs may be the link between genome and environment interactions.Additionally, a possible source of the reported immune activation in bipolar disorder is the micro biome of gastrointestinal tract, due torecent studies that indicate its pivotal role in brain function through the ‘gut-brain’ axis. The identification of methods able to modulate themicro biome emerges as a promising path for novel diagnostic and treatment options in bipolar disorder, thus the number of metagenomicstudies in bipolar disorder has substantially increased the last years. Overall, the paper aims to review the most recent literature ongenomic, epigenomic and metagenomic studies that have contributed to our understanding of the pathophysiology of bipolar disorder sofar. The paper also focuses on the exploitation of recent advancements in high-throughput technologies for the elucidation of bipolardisorder through different approaches that may provide complementary knowledge and concludes to the need for merging the gap betweenall the gathered knowledge from the analysis of high-throughput data.

sted, utgiver, år, opplag, sider
SciTech Central Inc. , 2019. Vol. 2, nr 1, s. 56-66
Emneord [en]
Bipolar disorder, Whole exome sequencing, Whole genome sequencing, Metagenomics, Epigenomics, RNA sequencing
HSV kategori
Forskningsprogram
Psykiatri; Medicin; Biomedicin
Identifikatorer
URN: urn:nbn:se:oru:diva-73695OAI: oai:DiVA.org:oru-73695DiVA, id: diva2:1304803
Prosjekter
Experimentell neuropsykiatriTilgjengelig fra: 2019-04-13 Laget: 2019-04-13 Sist oppdatert: 2019-04-24bibliografisk kontrollert

Open Access i DiVA

Recent Advancements in Bipolar Disorder studies through Genomic, Epigenomic and Metagenomic Approaches(800 kB)55 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 800 kBChecksum SHA-512
70c1d70473df8ca68250bffd0853a25e2160f89622c3cde456b77c9e911f1a3784e5719cf9e424b54c6ffa82514e1e8aea0423d1001ad8bf5e451854336a39ab
Type fulltextMimetype application/pdf

Andre lenker

http://www.scitcentral.com/article.php?journal=30&article=322&article_title=Recent Advancements in Bipolar Disorder studies through Genomic, Epigenomic and Metagenomic Approaches

Personposter BETA

Venizelos, Nikolaos

Søk i DiVA

Av forfatter/redaktør
Venizelos, Nikolaos
Av organisasjonen

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 55 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

urn-nbn

Altmetric

urn-nbn
Totalt: 170 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf