oru.sePublikasjoner
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
The Effect of Allogenic Versus Autologous Fecal Microbiota Transfer on Symptoms, Visceral Perception and Fecal and Mucosal Microbiota in Irritable Bowel Syndrome: A Randomized Controlled Study
Örebro universitet, Institutionen för medicinska vetenskaper. (Nutrition-Gut-Brain Interactions Research Centre)ORCID-id: 0000-0002-4204-6811
Örebro universitet, Institutionen för medicinska vetenskaper. (Nutrition-Gut-Brain Interactions Research Centre)ORCID-id: 0000-0003-3887-9519
Örebro universitet, Institutionen för medicinska vetenskaper. (Nutrition-Gut-Brain Interactions Research Centre)ORCID-id: 0000-0002-7173-5579
Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Vise andre og tillknytning
2019 (engelsk)Inngår i: Clinical and Translational Gastroenterology, ISSN 2155-384X, E-ISSN 2155-384X, Vol. 10, nr 4, artikkel-id e00034Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

OBJECTIVES: Fecal microbiota transfer (FMT) is suggested as a potential treatment for patients with irritable bowel syndrome (IBS). We aimed to study the effect of allogenic and autologous FMT on IBS symptoms, visceral sensitivity, and compositional changes in fecal and mucosa-adherent microbiota.

METHODS: Seventeen patients with IBS were randomized either to receive fecal material from a healthy donor (allogenic) or to receive their own fecal material (autologous). The fecal material was administered into the cecum by whole colonoscopy after bowel cleansing.

RESULTS: No significant differences were found between the allogenic and the autologous FMT regarding symptom scores. However, symptom scores of patients receiving allogenic fecal material significantly decreased after FMT compared with baseline (P 5 0.02), which was not the case in the autologous group (P50.16). Visceral sensitivity was not affected except for a small beneficial effect on urge scores in the autologous group (P < 0.05). While both fecal and mucosa-adherent microbiota of some patients shifted to their respective donor’s fecal microbiota, some patients showed no relevant microbial changes after allogenic FMT. Large compositional shifts in fecal and mucosa-adherent microbiota also occurred in the autologous group.

CONCLUSIONS: This study showed that a single FMT by colonoscopy may have beneficial effects in IBS; however, the allogenic fecal material was not superior to the autologous fecal material. This suggests that bowel cleansing prior to the colonoscopy and/or processing of the fecal material as part of the FMT routine contribute to symptoms and gut microbiota composition changes in IBS.

sted, utgiver, år, opplag, sider
Nature Publishing Group, 2019. Vol. 10, nr 4, artikkel-id e00034
HSV kategori
Forskningsprogram
Medicin
Identifikatorer
URN: urn:nbn:se:oru:diva-74035DOI: 10.14309/ctg.0000000000000034ISI: 000466787000001PubMedID: 31009405OAI: oai:DiVA.org:oru-74035DiVA, id: diva2:1313864
Forskningsfinansiär
Swedish Nutrition Foundation (SNF)
Merknad

Funding Agencies:

SIAM Gravitation Grant  024.002.002 

Spinoza 2008 Award of the Netherlands Organization for Scientific Research (NWO) 

Tilgjengelig fra: 2019-05-06 Laget: 2019-05-06 Sist oppdatert: 2019-06-19bibliografisk kontrollert

Open Access i DiVA

The Effect of Allogenic Versus Autologous Fecal Microbiota Transfer on Symptoms, Visceral Perception and Fecal and Mucosal Microbiota in Irritable Bowel Syndrome: A Randomized Controlled Study(824 kB)30 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 824 kBChecksum SHA-512
35ddb26f339da6410ab1e75868088dca25707644f4ba8b31af8a8113da3d706d3090d4ff92e05624aa75e592f31caee18738ff05720d71a25cecd1fbdba8275d
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Holster, SavanneLindqvist, Carl MårtenRepsilber, DirkKönig, JuliaBrummer, Robert Jan

Søk i DiVA

Av forfatter/redaktør
Holster, SavanneLindqvist, Carl MårtenRepsilber, DirkKönig, JuliaBrummer, Robert Jan
Av organisasjonen
I samme tidsskrift
Clinical and Translational Gastroenterology

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 30 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 121 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf