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Circulating inflammation markers and prostate cancer
Department of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.
Örebro universitet, Institutionen för medicinska vetenskaper. Region Örebro län. Department of Urology.ORCID-id: 0000-0001-5533-7899
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Vise andre og tillknytning
2019 (engelsk)Inngår i: The Prostate, ISSN 0270-4137, E-ISSN 1097-0045, Vol. 79, nr 11, s. 1338-1346Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: Chronic inflammation is thought to influence the risk of prostate cancer. The purpose of this population-based case-control study was to evaluate the association of 48 circulating inflammation markers with prostate cancer, to identify candidate markers for further investigation.

METHODS: Serum samples collected from 235 prostate cancer patients and 198 population-based controls recruited in Örebro County, Sweden, in 1989-1991, were assessed using a multiplex bead-based immunoassay to determine concentrations of 48 circulating inflammation markers. Logistic regression was first used to evaluate the association between individual markers (highest vs lowest concentration quartile) and prostate cancer in unadjusted and mutually adjusted models. Second, patients with inflammatory conditions, metastatic or advanced prostate cancer, were excluded to address the possible influence of systemic disease on inflammation markers.

RESULTS: Individual analyses first identified 21 markers associated with prostate cancer (P < .05), which after mutual adjustment were reduced to seven markers. After the exclusion of men with conditions linked with systemic inflammation, associations between prostate cancer and deviant levels of C-X3-C motif chemokine ligand 1, platelet-derived growth factor subunit B homodimer, interleukin 10, C-C motif chemokine ligand (CCL) 21, and CCL11 remained statistically significant.

CONCLUSIONS: In this explorative study, we identified candidate inflammation markers of possible importance for prostate cancer pathophysiology, for further evaluation in prospective studies.

sted, utgiver, år, opplag, sider
Alan R. Liss Inc. , 2019. Vol. 79, nr 11, s. 1338-1346
Emneord [en]
Circulating, cytokines, inflammation, markers, prostate cancer
HSV kategori
Identifikatorer
URN: urn:nbn:se:oru:diva-74753DOI: 10.1002/pros.23842ISI: 000473235500014PubMedID: 31212389Scopus ID: 2-s2.0-85068041866OAI: oai:DiVA.org:oru-74753DiVA, id: diva2:1328099
Merknad

Funding Agency:

Lions Cancerforskningsfond vid Akademiska sjukhuset i Uppsala. (Part of Lions International)

Tilgjengelig fra: 2019-06-20 Laget: 2019-06-20 Sist oppdatert: 2019-08-09bibliografisk kontrollert

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