Use of the biodegradable polymer chitosan as a vehicle for applying drugs to the inner ear
2010 (English)In: European Journal of Pharmaceutical Sciences, ISSN 0928-0987, E-ISSN 1879-0720, Vol. 39, no 1-3, p. 110-115Article in journal (Refereed) Published
Abstract [en]
Development of efficient local delivery systems for the auditory organ has an important role in clinical practice for the management of inner ear disorders using pharmacological means. Chitosan, a biodegradable polymer, is a good drug carrier with bioadhesive properties. The aim of this study was to investigate the feasibility of using chitosan to deliver drugs to the inner ear across the round window membrane (RWM). Three structurally different chitosans loaded with a tracer drug, neomycin, were injected into the middle ear cavity of albino guinea pigs (n=35). After 7 days the effect of chitosans and neomycin was compared among the treatment groups. The hearing organ was analysed for hair cell loss and the RWM evaluated in term of thickness. All tested chitosan formulations successfully released the loaded neomycin which then diffused across the RWM, and exerted ototoxic effect on the cochlear hair cells in a degree depending on the concentrations used. Chitosans per se had no noxious effect on the cochlear hair cells. It is concluded that the chitosans, and especially glycosylated derivative, are safe and effective carriers for inner ear therapy.
Place, publisher, year, edition, pages
Elsevier, 2010. Vol. 39, no 1-3, p. 110-115
Keywords [en]
Round window membrane, Chitosan, Hair cell, Drug delivery
National Category
Pharmaceutical Sciences
Research subject
Oto-Rhino-Laryngology; Biology
Identifiers
URN: urn:nbn:se:oru:diva-75076DOI: 10.1016/j.ejps.2009.11.003ISI: 000274672300016PubMedID: 19931387Scopus ID: 2-s2.0-73749087296OAI: oai:DiVA.org:oru-75076DiVA, id: diva2:1336841
Funder
Forte, Swedish Research Council for Health, Working Life and WelfareSwedish Research Council
Note
Research funders:
European Commission FP6, EUROHEAR (LSHG-CT-20054-512063)
Tysta Skolan Foundation
Petrus and Augusta Hedlund Foundation
Hawler Medical University-Iraq (HMU)
2019-07-102019-07-102019-08-07Bibliographically approved
In thesis