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Anthropometric measures at age 3 years in associations with prenatal and postnatal exposures to chlorophenols
School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China.
School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China.
School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China.
School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China.
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2019 (engelsk)Inngår i: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 228, s. 204-211Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Chlorophenols (CPs), suspected as endocrine disrupting chemicals, exposure during early life may contribute to body size. However, limited human data with inconsistent findings have examined the developmental effects of CPs exposure.

Objective: To explore associations between prenatal and postnatal CPs exposure and anthropometric parameters in children aged 3 years.

Methods: A subset of 377 mother-child pairs with urinary five CP concentrations were enrolled from a prospective birth cohort. Generalized linear models were conducted to evaluate associations of CPs exposure with children's anthropometric measures.

Results: Maternal urinary 2,4,6-trichlorophenol (2,4,6-TCP) concentrations were significantly negatively associated with weight z scores [regression coefficient (beta)=-0.51, 95% confidence interval (Cl): -0.96, -0.05; p = 0.01], weight for height z scores (beta = -0.54, 95% Cl:-1.02, -0.06; p= 0.01) and body mass index (BMI) z scores (beta = -0.53, 95% CI;-1.03, 0.03; p = 0.01) of children aged 3 years, after adjustment for potential confounders and postnatal CPs exposure. In the sex-stratified analyses, these inverse associations remained among boys, while in girls, positive associations of prenatal 2,4,6-TCP exposure with weight for height z scores and BMI z scores were observed. Postnatal exposure to 2,5-diclorophenol (2,5-DCP) was positively associated with weight z scores (beta = 0.26, 95% CI: 0.02, 0.50; p = 0.04), after controlling for possible confounders and maternal CPs exposure during pregnancy. Considering potential sex-specific effects, these associations were only observed in girls.

Conclusions: Our findings indicate that prenatal 2,4,6-TCP exposure and postnatal 2,5-DCP exposure may have adverse and sex-specific effects on children's physical development.

sted, utgiver, år, opplag, sider
Elsevier, 2019. Vol. 228, s. 204-211
Emneord [en]
Chlorophenols, Prenatal exposure, Childhood exposure, Anthropometric measures, Prospective birth cohort
HSV kategori
Identifikatorer
URN: urn:nbn:se:oru:diva-75201DOI: 10.1016/j.chemosphere.2019.04.127ISI: 000471084700023PubMedID: 31029966Scopus ID: 2-s2.0-85064663097OAI: oai:DiVA.org:oru-75201DiVA, id: diva2:1339243
Merknad

Funding Agencies:

National Natural Science Foundation of China  NSFC-STINT 81611130087 

Natural Science Foundation of Shanghai, China  18ZR1404200 

Shanghai Municipal Health Commission  201640037 

Shanghai "3-Year Action" Project  GWIV-27.3 

Tilgjengelig fra: 2019-07-26 Laget: 2019-07-26 Sist oppdatert: 2019-07-26bibliografisk kontrollert

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