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Application value of CyTOF 2 mass cytometer technology at single-cell level in human gastric cancer cells
Departments of Endoscopy Center, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Departments of General Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Department of Oncology and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Örebro universitet, Institutionen för medicinska vetenskaper.
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2019 (Engelska)Ingår i: Experimental Cell Research, ISSN 0014-4827, E-ISSN 1090-2422, Vol. 384, nr 1, artikel-id 111568Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Chemotherapy and radiotherapy are main adjuvant therapies for the treatment of gastric cancer, the treatment effects are individual difference, but the specific mechanism is unknown. CyTOF 2 mass cytometer (CyTOF) enables the detecting up to 135 parameters on single cell, the emergence of which is an opportunity for proteomics research. We first tried to apply CyTOF technique to gastric cancer cells. We verified applicability of CyTOF in gastric cancer cells, and analyzed the responses of seventeen proteins to chemoradiotherapy in human gastric cancer AGS cells. To analyze the high dimensional CyTOF data, we used two statistical and visualization tools including viSNE and Citrus. Two specific clusters were found which had differences in protein expression profiles. CyTOF technology is proved feasibility and value at single cell level of gastric cancer.

Ort, förlag, år, upplaga, sidor
Elsevier, 2019. Vol. 384, nr 1, artikel-id 111568
Nyckelord [en]
Citrus, Gastric cancer, Mass cytometry, Single-cell, viSNE
Nationell ämneskategori
Cancer och onkologi
Identifikatorer
URN: urn:nbn:se:oru:diva-75898DOI: 10.1016/j.yexcr.2019.111568ISI: 000490031700024PubMedID: 31446162Scopus ID: 2-s2.0-85072229049OAI: oai:DiVA.org:oru-75898DiVA, id: diva2:1349496
Anmärkning

Funding Agencies:

Hebei Province Key Research and Development Project  18277741D

International Science & Technology Cooperation Program of China  2014DFA31150

Hebei Province Projects  1387 SGH201501 A201802017 LNB201809 G2019035

Tillgänglig från: 2019-09-09 Skapad: 2019-09-09 Senast uppdaterad: 2019-11-15Bibliografiskt granskad

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