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Increased plasma cathepsin S and trombospondin-1 in patients with acute ST-segment elevation myocardial infarction
Örebro University, School of Medical Sciences. Department of Laboratory Medicine, Section for Transfusion Medicine.
Department of Cardiology, Örebro University Hospital, Örebro, Sweden.
Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Örebro University, School of Medical Sciences. Cardiovascular Research Centre,.
2019 (English)In: Cardiology Journal, ISSN 1897-5593, Vol. 26, no 4, p. 385-393Article in journal (Refereed) Published
Abstract [en]

Background: The role of cathepsins in the pathological progression of atherosclerotic lesions in ischemic heart disease have been defined in detail more than numerous times. This investigation examined the platelet-specific biomarker trombospondin-1 (TSP-1) and platelet function ex vivo, and compared this with cathepsin S (Cat-S; a biomarker unrelated to platelet activation but also associated this with increased mortality risk) in patients with ST-segment elevation myocardial infarction (STEMI).

Methods: The STEMI patients were divided into two groups depending on the degree of coronary vessel occlusion: those with closed (n = 90) and open culprit vessel (n = 40). Cat-S and TSP-1 were analyzed before, 1-3 days after and 3 months after percutanous coronary intervention (PCI).

Results: During acute STEMI, plasma TSP-1 was significantly elevated in patients with closed culprit lesions, but rapidly declined after PCI. In fact, TSP-1 after PCI was significantly lower inpatient samples compared to healthy individuals. In comparison, plasma Cat-S was significantly elevated both before and after PCI. In patients with closed culprit lesions, Cat-S was significantly higher compared to patients with open culprit lesions 3 months after PCI. Although troponin-I were higher (p < 0.01) in patients with closed culprit lesion, there was no correlation with Cat-S and TSP-1.

Conclusions: Cat-S but not TSP-1 may be a useful risk biomarker in relation to the severity of STEMI. However, the causality of Cat-S as a predictor for long-term mortality in STEMI remains to be ascertained in future studies.

Place, publisher, year, edition, pages
Via Medica , 2019. Vol. 26, no 4, p. 385-393
Keywords [en]
ST-segment elevation myocardial infarction, cathepsin S, percutaneous coronary intervention, platelets
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:oru:diva-76449DOI: 10.5603/CJ.a2018.0030ISI: 000483031700010PubMedID: 29611169Scopus ID: 2-s2.0-85071630437OAI: oai:DiVA.org:oru-76449DiVA, id: diva2:1351580
Note

Funding Agency:

Örebro University Hospital Research Foundation AFA Insurance 

Available from: 2019-09-16 Created: 2019-09-16 Last updated: 2019-09-16Bibliographically approved

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Befekadu, RahelGrenegård, Magnus

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