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Prognostic significance of faecal eosinophil granule proteins in inflammatory bowel disease
Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Department of Medical Sciences, Gastroenterology Research Group, Uppsala University, Uppsala, Sweden.
Örebro universitet, Institutionen för medicinska vetenskaper. Region Örebro län. Unit of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. (Clinical Epidemiology and Biostatistics)ORCID-id: 0000-0002-3552-9153
Region Örebro län. Örebro universitet, Institutionen för medicinska vetenskaper. Department of Gastroenterology.
Department of Medical Sciences, Gastroenterology Research Group, Uppsala University, Uppsala, Sweden.
Vise andre og tillknytning
2019 (engelsk)Inngår i: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, E-ISSN 1502-7708, s. 1-8Artikkel i tidsskrift (Fagfellevurdert) Epub ahead of print
Abstract [en]

Background: Non-invasive markers for predicting relapse would be a useful tool for the management of patients with inflammatory bowel disease. Eosinophil granulocytes and their granule proteins eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN) have previously been shown to reflect disease activity in Crohn's disease and ulcerative colitis.

Aim: To examine the capacity of faecal ECP and EDN to predict relapse in ulcerative colitis and Crohn's disease, and to compare these proteins with faecal calprotectin.

Methods: Patients with Crohn's disease (n=49) and ulcerative colitis (n=55) were followed prospectively until relapse or end of the two-year study period. Faecal samples were obtained every third month. The predictive value of ECP and EDN was assessed in Cox regression models.

Results: In ulcerative colitis, a doubled EDN or ECP concentration was associated with a 31% and 27% increased risk of relapse, respectively. EDN levels were increased both at relapse and three months prior. By contrast, in Crohn's disease, the concentration of EDN was higher among patients in remission than in those who relapsed. Correlations between faecal calprotectin, ECP and EDN were observed in both diseases.

Conclusions: We demonstrate that the risk of relapse in ulcerative colitis can be predicted by consecutively measuring faecal EDN every third month, and suggest EDN as a complementary faecal marker to calprotectin to predict future relapse in ulcerative colitis. Our finding of higher EDN in Crohn's disease-patients staying in remission than in those who relapsed indicates different functions of the protein in ulcerative colitis and Crohn's disease.

sted, utgiver, år, opplag, sider
Taylor & Francis, 2019. s. 1-8
Emneord [en]
Crohn's disease, Inflammatory bowel disease, biomarkers, eosinophils, inflammation, ulcerative colitis
HSV kategori
Identifikatorer
URN: urn:nbn:se:oru:diva-77028DOI: 10.1080/00365521.2019.1670251ISI: 000488503800001PubMedID: 31577465OAI: oai:DiVA.org:oru-77028DiVA, id: diva2:1358124
Forskningsfinansiär
Swedish Foundation for Strategic Research , RB13-0160Swedish Research Council, 521-2011-2764
Merknad

Funding Agencies:

Medical Faculty, Uppsala University, Uppsala Sweden  

Örebro University Hospital Research Foundation  OLL-333321

Uppsala-Örebro Regional Research Foundation  RFR-314671

Tilgjengelig fra: 2019-10-07 Laget: 2019-10-07 Sist oppdatert: 2019-10-14bibliografisk kontrollert

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