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Validation of a medium-throughput method for evaluation of intracellular growth of Mycobacterium tuberculosis
Division of Medical Microbiology, Linköping University, Linköping, Sweden.
Division of Medical Microbiology, Linköping University, Linköping, Sweden.
Department of Clinical Microbiology and Infectious Diseases, Kalmar County Hospital, Kalmar, Sweden.
Division of Medical Microbiology, Linköping University, Linköping, Sweden.
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2010 (Engelska)Ingår i: Clinical and Vaccine Immunology, ISSN 1556-6811, E-ISSN 1556-679X, Vol. 17, nr 4, s. 513-517Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Intracellular pathogens such as Mycobacterium tuberculosis have adapted to a life inside host cells, in which they utilize host nutrients to replicate and spread. Ineffective methods for the evaluation of growth of intracellular pathogens in their true environment pose an obstacle for basic research and drug screening. Here we present the validation of a luminometry-based method for the analysis of intramacrophage growth of M. tuberculosis. The method, which is performed in a medium-throughput format, can easily be adapted for studies of other intracellular pathogens and cell types. The use of host cells in drug-screening assays dedicated to find antimicrobials effective against intracellular pathogens permits the discovery of not only novel antibiotics but also compounds with immunomodulatory and virulence-impairing activities, which may be future alternatives or complements to antibiotics.

Ort, förlag, år, upplaga, sidor
American Society for Microbiology , 2010. Vol. 17, nr 4, s. 513-517
Nationell ämneskategori
Infektionsmedicin Mikrobiologi inom det medicinska området
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URN: urn:nbn:se:oru:diva-77089DOI: 10.1128/CVI.00446-09ISI: 000276170900004PubMedID: 20107000Scopus ID: 2-s2.0-77950686614OAI: oai:DiVA.org:oru-77089DiVA, id: diva2:1358734
Tillgänglig från: 2019-10-08 Skapad: 2019-10-08 Senast uppdaterad: 2019-10-08Bibliografiskt granskad

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