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Celiac disease and complement activation in response to Streptococcus pneumoniae
Department of Pediatrics, Kalmar County Hospital, Kalmar, Sweden; School of Medical Sciences, Örebro University, Örebro, Sweden.
Research section, Department of Development and Public Health, Kalmar County Hospital, Kalmar, Sweden.
Linnaeus Center for Biomaterials Chemistry, Linnaeus University, Kalmar, Sweden.
Department of Clinical Microbiology, Kalmar County Hospital, Kalmar, Sweden; Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
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2020 (Engelska)Ingår i: European Journal of Pediatrics, ISSN 0340-6199, E-ISSN 1432-1076, Vol. 179, nr 1, s. 133-140Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Individuals with celiac disease (CD) are at increased risk of invasive pneumococcal disease (IPD). The aim of this study was to explore whether the complement response to Streptococcus pneumoniae differed according to CD status, and could serve as an explanation for the excess risk of IPD in CD. Twenty-two children with CD and 18 controls, born 1999-2008, were included at Kalmar County Hospital, Sweden. The degree of complement activation was evaluated by comparing levels of activation products C3a and sC5b-9 in plasma incubated for 30 min with Streptococcus pneumoniae and in non-incubated plasma. Complement analyses were performed with enzyme-linked immunosorbent assay (ELISA). Pneumococcal stimulation caused a statistically significant increase in C3a as well as sC5b-9 in both children with CD and controls but there was no difference in response between the groups. After incubation, C3a increased on average 4.6 times and sC5b-9 22 times in both the CD and the control group (p = 0.497 and p = 0.724 respectively). Conclusion: Complement response to Streptococcus pneumoniae seems to be similar in children with and without CD and is thus unlikely to contribute to the increased susceptibility to invasive pneumococcal disease in CD.

Ort, förlag, år, upplaga, sidor
Springer, 2020. Vol. 179, nr 1, s. 133-140
Nyckelord [en]
Coeliac, Pneumococcal, Infection, Innate immunity, MBL
Nationell ämneskategori
Pediatrik
Identifikatorer
URN: urn:nbn:se:oru:diva-77992DOI: 10.1007/s00431-019-03490-wISI: 000494392200001PubMedID: 31691001Scopus ID: 2-s2.0-85074845938OAI: oai:DiVA.org:oru-77992DiVA, id: diva2:1372300
Forskningsfinansiär
Vetenskapsrådet, 522-2A09-195 2016-2075-5.1 2018-04087
Anmärkning

Funding Agencies:

Medical Research Council of Southeast Sweden  658741

Region Kalmar County 

Swedish Celiac Society 

Fulbright Commission  

Linnaeus University  

Research Council of Norway 274332

Örebro University 

Tillgänglig från: 2019-11-22 Skapad: 2019-11-22 Senast uppdaterad: 2020-01-13Bibliografiskt granskad

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Ludvigsson, Jonas F.

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European Journal of Pediatrics
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