CSF/serum folate gradient: physiology and determinants with special reference to dementia
2008 (English)In: Dementia and Geriatric Cognitive Disorders, ISSN 1420-8008, E-ISSN 1421-9824, Vol. 25, no 6, p. 516-523Article in journal (Refereed) Published
Abstract [en]
BACKGROUND: Folate depletion has been implicated as a risk factor for neurodegenerative disorders. We hypothesized that transport of folate to the cerebrospinal fluid (CSF) compartment could be involved in the pathophysiology of these disorders.
METHODS: The CSF/serum folate gradient (R(CSF/S)) was studied in 205 subjects with suspected cognitive disorder. Its relation to clinical and biochemical indices, including the integrity of the blood-CSF barrier, were characterized.
RESULTS: In subjects who were diagnosed as nondemented (ND) the mean R(CSF/S )+/- SD was 2.46 +/- 0.62 versus 2.09 +/- 0.67 (p = 0.008) in the dementia subgroup with a vascular component (VaD + mixed). The ND subgroup had higher CSF folate (p = 0.001) and lower serum homocysteine values (p = 0.001) than the VaD + mixed subgroup. The folate gradient R(CSF/S) was negatively correlated with serum folate (p < 0.001, R(2) = 0.518) and to the albumin ratio, a blood-CSF barrier biomarker (beta = -0.235). The Alzheimer patients had R(CSF/S) and albumin ratios similar to the ND subjects.
CONCLUSION: The R(CSF/S) was significantly lower in the VaD + mixed dementia subgroup, suggestive of a defect in the transport of folate over the choroid plexus that seems to be characteristic of, and limited to, the VaD + mixed dementia subgroup.
Place, publisher, year, edition, pages
S. Karger, 2008. Vol. 25, no 6, p. 516-523
Keywords [en]
Aged, Aged; 80 and over, Alzheimer Disease/blood/cerebrospinal fluid/epidemiology, Blood-Brain Barrier/*physiology, Case-Control Studies, Choroid Plexus/metabolism, Dementia; Vascular/blood/cerebrospinal fluid/epidemiology, Female, Folic Acid/*blood/*cerebrospinal fluid, Homocysteine/blood, Humans, Linear Models, Male, Middle Aged, Multivariate Analysis, Risk Factors, Serum Albumin/metabolism, Vitamin B 12/blood
National Category
Medical and Health Sciences Physiology
Research subject
Physiology
Identifiers
URN: urn:nbn:se:oru:diva-3509DOI: 10.1159/000129696ISI: 000257515500005PubMedID: 18463447Scopus ID: 2-s2.0-46849103183OAI: oai:DiVA.org:oru-3509DiVA, id: diva2:137806
2008-12-082008-12-082022-07-07Bibliographically approved
In thesis