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Evidence of a prominent genetic basis for associations between psychoneurometric traits and common mental disorders
Florida State University, Tallahassee FL, USA.
University of Michigan, Ann Arbor MI, USA.
Florida State University, Tallahassee FL, USA.
Veterans Affairs Medical Center, Minneapolis MN, USA.
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2017 (English)In: International Journal of Psychophysiology, ISSN 0167-8760, E-ISSN 1872-7697, Vol. 115, p. 4-12Article in journal (Refereed) Published
Abstract [en]

Threat sensitivity (THT) and weak inhibitory control (or disinhibition; DIS) are trait constructs that relate to multiple types of psychopathology and can be assessed psychoneurometrically (i.e., using self-report and physiological indicators combined). However, to establish that psychoneurometric assessments of THT and DIS index biologically-based liabilities, it is important to clarify the etiologic bases of these variables and their associations with clinical problems. The current work addressed this important issue using data from a sample of identical and fraternal adult twins (N = 454). THT was quantified using a scale measure and three physiological indicators of emotional reactivity to visual aversive stimuli. DIS was operationalized using scores on two scale measures combined with two brain indicators from cognitive processing tasks. THT and DIS operationalized in these ways both showed appreciable heritability (0.45, 0.68), and genetic variance in these traits accounted for most of their phenotypic associations with fear, distress, and substance use disorder symptoms. Our findings suggest that, as indices of basic dispositional liabilities for multiple forms of psychopathology with direct links to neurophysiology, psychoneurometric assessments of THT and DIS represent novel and important targets for biologically-oriented research on psychopathology.

Place, publisher, year, edition, pages
Amsterdam: Elsevier, 2017. Vol. 115, p. 4-12
Keywords [en]
Psychopathology, Mental disorders, Internalizing, Externalizing, Inhibitory control, Disinhibition, Threat sensitivity, Fear
National Category
Psychology
Identifiers
URN: urn:nbn:se:oru:diva-78679DOI: 10.1016/j.ijpsycho.2016.09.011ISI: 000401047900002PubMedID: 27671504Scopus ID: 2-s2.0-85000580229OAI: oai:DiVA.org:oru-78679DiVA, id: diva2:1379474
Note

Funding Agencies:

United States Department of Health & Human Services

National Institutes of Health (NIH) - USA

NIH National Institute of Mental Health (NIMH) P50 MH072850RC1 MH089727

United States Department of Defense W911NF-14-1-0027

Available from: 2019-12-17 Created: 2019-12-17 Last updated: 2019-12-18Bibliographically approved

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Kramer, Mark

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