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Inhibition of bombesin-induced mitogenesis by pertussis toxin: Dissociation from phospholipase C pathway.
Imperial Cancer Research Fund, London, U.K..
Imperial Cancer Research Fund, London, U.K..
Imperial Cancer Research Fund, London, U.K..ORCID iD: 0000-0001-8889-5803
Imperial Cancer Research Fund, London, U.K..
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1987 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 146, no 2, p. 456-463Article in journal (Refereed) Published
Abstract [en]

Prior incubation of quiescent cultures of Swiss 3T3 cells with pertussis toxin selectively inhibited the stimulation of DNA synthesis induced by peptides of the bombesin family. While pertussis toxin blocked mitogenesis at an early stage in the action of the peptide, the toxin did not impair the rapid stimulation of polyphosphoinositide breakdown, Ca2+ mobilization or activation of protein kinase C promoted by bombesin. Thus, inhibition of bombesin-induced mitogenesis by pertussis toxin can be dissociated from inactivation of the phospholipase C signalling pathway.

Place, publisher, year, edition, pages
Academic Press, 1987. Vol. 146, no 2, p. 456-463
National Category
Medical and Health Sciences Cell and Molecular Biology
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URN: urn:nbn:se:oru:diva-79070DOI: 10.1016/0006-291x(87)90551-1ISI: A1987J346200012PubMedID: 3039979Scopus ID: 2-s2.0-0023216738OAI: oai:DiVA.org:oru-79070DiVA, id: diva2:1386247
Available from: 2013-10-21 Created: 2020-01-17 Last updated: 2020-01-27Bibliographically approved

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Nånberg, Eewa

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