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Increased expired NO and roles of CO2 and endogenous NO after venous gas embolism in rabbits
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.ORCID-id: 0000-0002-8461-5074
Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.
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2006 (engelsk)Inngår i: European Journal of Applied Physiology, ISSN 1439-6319, E-ISSN 1439-6327, Vol. 97, nr 2, s. 210-215Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Venous gas embolism (VGE) is a feared complication in diving, aviation, surgery and trauma. We hypothesized that air emboli in the lung circulation might change expired nitric oxide (FeNO). A single intravenous infusion of air was given (100 mul kg(-1)) to three groups of anaesthetized mechanically ventilated rabbits: (A) one with intact NO production, (B) one with intact NO production and where end-tidal CO(2) was controlled, and (C) one with endogenous NO synthesis blockade (L: -NAME, 30 mg kg(-1)). Air infusions resulted in increased FeNO of the control group from 20 (4) [mean (SD)] ppb to a peak value of 39 (4) ppb within 5 min (P < 0.05), and FeNO was still significantly elevated [27 (2) ppb] after 20 min (P < 0.05). Parallel to the NO increase there were significant decreases in end-tidal CO(2 )(ETCO(2)) and mean arterial pressure and an increase in insufflation pressure. In group B, when CO(2) was supplemented after air infusion, NO was suppressed (P = 0.033), but was still significantly elevated compared with pre-infusion control (P < 0.05). In group C, all animals died within 40 min of air infusion whereas all animals in the other groups were still alive at this time point. We conclude that venous air embolization increases FeNO, and that a part of this effect is due to the concomitant decrease in ETCO(2). Furthermore, an intact NO production may be critical for the tolerance to VGE. Finally, FeNO might have a potential in the diagnosis and monitoring of pulmonary gas embolism.

sted, utgiver, år, opplag, sider
Heidelberg, Germany: Springer Berlin/Heidelberg, 2006. Vol. 97, nr 2, s. 210-215
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URN: urn:nbn:se:oru:diva-79261DOI: 10.1007/s00421-006-0179-8ISI: 000238668000009PubMedID: 16628452Scopus ID: 2-s2.0-33745441084OAI: oai:DiVA.org:oru-79261DiVA, id: diva2:1386990
Tilgjengelig fra: 2020-01-20 Laget: 2020-01-20 Sist oppdatert: 2020-02-27bibliografisk kontrollert

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