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Increased inflammasome activity in markedly ill psychiatric patients: An explorative study
Örebro University, School of Medical Sciences. University Health Care Research Center. (Inflammatory Response and Infection Susceptibility Centre, (iRiSC))ORCID iD: 0000-0002-3587-6075
Örebro University, School of Medical Sciences. (Inflammatory Response and Infection Susceptibility Centre, (iRiSC))
Örebro University, School of Medical Sciences. University Health Care Research Center. (Inflammatory Response and Infection Susceptibility Centre, (iRiSC))ORCID iD: 0000-0001-6726-7787
School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
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2020 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 339, article id 577119Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to investigate inflammatory perturbations in 40 patients with severe and complex psychiatric disorders by studying the activity of the NLRP3 inflammasome, with a trans-diagnostic approach. Gene expression of CASP1, NLRP3, PYCARD, IL1B, IL1RN, TNF showed a significant increase in the patient group compared to a matched control group. Plasma levels of IL1Ra, IL-18, TNF, IL-6 and CRP were increased in the patient group. Within the patient group, increased gene expression of inflammatory markers correlated with increased disease severity. The findings support the inflammation hypothesis for markedly ill psychiatric patients across diagnostic groups.

Place, publisher, year, edition, pages
Elsevier, 2020. Vol. 339, article id 577119
National Category
Psychiatry Immunology in the medical area
Identifiers
URN: urn:nbn:se:oru:diva-79288DOI: 10.1016/j.jneuroim.2019.577119ISI: 000510528000013PubMedID: 31786499Scopus ID: 2-s2.0-85075532475OAI: oai:DiVA.org:oru-79288DiVA, id: diva2:1387479
Note

Funding Agencies:

Region Örebro County (ALF)  

Region Örebro County (Research Committee)  

Faculty of Medicine and Health, Örebro University 

Available from: 2020-01-21 Created: 2020-01-21 Last updated: 2020-03-17Bibliographically approved

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Hylén, UlrikaEklund, DanielHumble, Mats B.Särndahl, EvaBejerot, Susanne

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