With the fast-growing use of nanoparticles (NPs) in a wide range of production and manufacturing processes, and great health and environmental risks associated to NPs, it is important to treat the industry-produced NPs in a proper way. Ventilation of industrial workplaces lies within the concept of sustainability challenges for the development of nanoproducts. Due to the decreased grain size of material to nano limits and thus the appearance of either new or changed properties, health risk of workers in such environments is critical concerning the complicated and unknown characteristics of nanoparticles. There is great evidence over the past few years that ultrafine particles and especially NPs in the breathing air are strong toxins. Different mitigation measures for air-borne nanoparticles in industrial workplaces are substitution, engineering controls such as ventilation and provision of personal protective equipment. In this paper selection criteria for ventilation systems and different ventilation methods (hood ventilation and global enclosure/room ventilation systems) as engineering controls of nanoparticles within industrial enclosures will be reviewed. Novel methods for improvement of ventilation efficiency in general and industrial work places with an eye on ventilation of nanoparticles will be presented.