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A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals
Department of Environmental Health Sciences, University of Massachusetts, Amherst, USA.
Department of Environmental Science and Analytical Chemistry, Stockholm University, Stockholm, Sweden.
Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
ANSES French Agcy Food Environm & Occupat Hlth Sa, Maisons Alfort, France.
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2016 (English)In: Environmental Health, E-ISSN 1476-069X, Vol. 15, no 1, article id 74Article in journal (Refereed) Published
Abstract [en]

Background: The issue of endocrine disrupting chemicals (EDCs) is receiving wide attention from both the scientific and regulatory communities. Recent analyses of the EDC literature have been criticized for failing to use transparent and objective approaches to draw conclusions about the strength of evidence linking EDC exposures to adverse health or environmental outcomes. Systematic review methodologies are ideal for addressing this issue as they provide transparent and consistent approaches to study selection and evaluation. Objective methods are needed for integrating the multiple streams of evidence (epidemiology, wildlife, laboratory animal, in vitro, and in silico data) that are relevant in assessing EDCs.

Methods: We have developed a framework for the systematic review and integrated assessment (SYRINA) of EDC studies. The framework was designed for use with the International Program on Chemical Safety (IPCS) and World Health Organization (WHO) definition of an EDC, which requires appraisal of evidence regarding 1) association between exposure and an adverse effect, 2) association between exposure and endocrine disrupting activity, and 3) a plausible link between the adverse effect and the endocrine disrupting activity.

Results: Building from existing methodologies for evaluating and synthesizing evidence, the SYRINA framework includes seven steps: 1) Formulate the problem; 2) Develop the review protocol; 3) Identify relevant evidence; 4) Evaluate evidence from individual studies; 5) Summarize and evaluate each stream of evidence; 6) Integrate evidence across all streams; 7) Draw conclusions, make recommendations, and evaluate uncertainties. The proposed method is tailored to the IPCS/WHO definition of an EDC but offers flexibility for use in the context of other definitions of EDCs.

Conclusions: When using the SYRINA framework, the overall objective is to provide the evidence base needed to support decision making, including any action to avoid/minimise potential adverse effects of exposures. This framework allows for the evaluation and synthesis of evidence from multiple evidence streams. Finally, a decision regarding regulatory action is not only dependent on the strength of evidence, but also the consequences of action/inaction, e.g. limited or weak evidence may be sufficient to justify action if consequences are serious or irreversible.

Place, publisher, year, edition, pages
London: BioMed Central (BMC), 2016. Vol. 15, no 1, article id 74
Keywords [en]
Endocrine disrupting chemicals, Systematic review, Study evaluation, Strength of evidence, Weight of evidence, Adverse effect, Endocrine disrupting activity, Evidence integration, Epidemiology, In vivo
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public Health Science
Identifiers
URN: urn:nbn:se:oru:diva-83039DOI: 10.1186/s12940-016-0156-6ISI: 000379994300001PubMedID: 27412149Scopus ID: 2-s2.0-84979687804OAI: oai:DiVA.org:oru-83039DiVA, id: diva2:1439303
Funder
Swedish Foundation for Strategic ResearchAcademy of Finland
Note

Ytterligare forskningsfinansiärer:

United States Department of Health & Human Services, National Institutes of Health (NIH) - USA, NIH National Institute of Environmental Health Sciences (NIEHS), Grant Number: K22ES025811

Clarence Heller Foundation, Grant Number: A123547

Passport Foundation

Forsythia Foundation

United States Department of Health & Human Services, National Institutes of Health (NIH) - USA, NIH National Institute of Environmental Health Sciences (NIEHS), Grant Number: ES018135, ESO22841

U.S. EPA STAR grant, Grant Number: RD83467801, RD83543301

Sigrid Juselius Foundation

Danish EPA

Canada Research Chairs, Grant Number: 950-230607

National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), Grant Number: NC/L000970/1

Available from: 2016-08-12 Created: 2020-06-12 Last updated: 2024-04-05Bibliographically approved

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Bornehag, Carl-GustafNorinder, Ulf

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