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Effects of Dietary Fibres on Acute Indomethacin-Induced Intestinal Hyperpermeability in the Elderly: A Randomised Placebo Controlled Parallel Clinical Trial
Örebro University, School of Medical Sciences. Orebro Univ, Fac Med & Hlth, Sch Med Sci, Sodra Grey Rosengatan 32, S-70362 Orebro, Sweden..ORCID iD: 0000-0002-2120-7743
Örebro University, School of Medical Sciences.ORCID iD: 0000-0002-5990-0009
Örebro University, School of Medical Sciences.
Örebro University, School of Medical Sciences.ORCID iD: 0000-0003-3887-9519
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2020 (English)In: Nutrients, E-ISSN 2072-6643, Vol. 12, no 7, article id 1954Article in journal (Refereed) Published
Abstract [en]

The effect of dietary fibres on intestinal barrier function has not been well studied, especially in the elderly. We aimed to investigate the potential of the dietary fibres oat beta-glucan and wheat arabinoxylan to strengthen the intestinal barrier function and counteract acute non-steroid anti-inflammatory drug (indomethacin)-induced hyperpermeability in the elderly. A general population of elderly subjects (>= 65 years,n= 49) was randomised to a daily supplementation (12g/day) of oat beta-glucan, arabinoxylan or placebo (maltodextrin) for six weeks. The primary outcome was change in acute indomethacin-induced intestinal permeability from baseline, assessed by an in vivo multi-sugar permeability test. Secondary outcomes were changes from baseline in: gut microbiota composition, systemic inflammatory status and self-reported health. Despite a majority of the study population (85%) showing a habitual fibre intake below the recommendation, no significant effects on acute indomethacin-induced intestinal hyperpermeability in vivo or gut microbiota composition were observed after six weeks intervention with either dietary fibre, compared to placebo.

Place, publisher, year, edition, pages
MDPI , 2020. Vol. 12, no 7, article id 1954
Keywords [en]
dietary fibres, prebiotics, intestinal permeability, NSAIDs, clinical trial, elderly, intestinal barrier function, gut health
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:oru:diva-85194DOI: 10.3390/nu12071954ISI: 000557667400001PubMedID: 32629992Scopus ID: 2-s2.0-85087167580OAI: oai:DiVA.org:oru-85194DiVA, id: diva2:1462232
Note

Funding Agencies:

European Union (EU) 289517

Bo Rydin foundation  F0514

Available from: 2020-08-28 Created: 2020-08-28 Last updated: 2025-02-11Bibliographically approved

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Ganda Mall, John PeterFart, FridaSabet, Julia A.Lindqvist, Carl MårtenBrummer, Robert JanSchoultz, Ida

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