Endometriosis is a disease that affects women. This article focuses on endometriosis communication outside of, but in relation to, institutionally organized health care. The discursive use of affects and emotions in endometriosis communication in internet forums, social media and the press is analyzed: Which emotions are represented? Which affective communities are readers invited into, and how is this performed? Drawing on appraisal analysis and affective discourse analysis, the article shows how not only negative affects, but also those of happiness and gratitude are represented, and how narratives and specific visual formats function as affective affordances that invite readers to become part of ‘endo-communities’.