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Multi-Strain Probiotic Mixture Affects Brain Morphology and Resting State Brain Function in Healthy Subjects: An RCT
Örebro University, School of Medical Sciences. (Nutrition-Gut-Brain Interactions Research Centre)ORCID iD: 0000-0001-9402-4756
Faculty of Medicine and Health, School of Medical Sciences, Örebro University, Örebro, Sweden. (Nutrition-Gut-Brain Interactions Research Centre)
Örebro University, School of Medical Sciences. (Nutrition-Gut-Brain Interactions Research Centre)ORCID iD: 0000-0003-0466-1861
Örebro University, School of Medical Sciences. (Nutrition-Gut-Brain Interactions Research Centre)
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2022 (English)In: Cells, E-ISSN 2073-4409, Vol. 11, no 18, article id 2922Article in journal (Refereed) Published
Abstract [en]

Probiotics can alter brain function via the gut-brain axis. We investigated the effect of a probiotic mixture containing Bifidobacterium longum, Lactobacillus helveticus and Lactiplantibacillus plantarum. In a randomized, placebo-controlled, double-blinded crossover design, 22 healthy subjects (6 m/16 f; 24.2 ± 3.4 years) underwent four-week intervention periods with probiotics and placebo, separated by a four-week washout period. Voxel-based morphometry indicated that the probiotic intervention affected the gray matter volume of a cluster covering the left supramarginal gyrus and superior parietal lobule (p < 0.0001), two regions that were also among those with an altered resting state functional connectivity. Probiotic intervention resulted in significant (FDR < 0.05) functional connectivity changes between regions within the default mode, salience, frontoparietal as well as the language network and several regions located outside these networks. Psychological symptoms trended towards improvement after probiotic intervention, i.e., the total score of the Hospital Anxiety and Depression Scale (p = 0.056) and its depression sub-score (p = 0.093), as well as sleep patterns (p = 0.058). The probiotic intervention evoked distinct changes in brain morphology and resting state brain function alongside slight improvements of psycho(bio)logical markers of the gut-brain axis. The combination of those parameters may provide new insights into the modes of action by which gut microbiota can affect gut-brain communication and hence brain function.

Place, publisher, year, edition, pages
MDPI, 2022. Vol. 11, no 18, article id 2922
Keywords [en]
CO2 inhalation challenge, autonomic nervous system, brain-derived neurotrophic factor (BDNF), cortisol awakening response, gut microbiota, mental health, resting state functional connectivity, serotonin, sleep quality, structural changes
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Neurology
Identifiers
URN: urn:nbn:se:oru:diva-101446DOI: 10.3390/cells11182922ISI: 000858164900001PubMedID: 36139496Scopus ID: 2-s2.0-85138356660OAI: oai:DiVA.org:oru-101446DiVA, id: diva2:1698593
Note

Funding agencies:

Global Medical Innovation

Pfizer Consumer Healthcare

General Electric 20150081

Available from: 2022-09-24 Created: 2022-09-24 Last updated: 2022-10-05Bibliographically approved

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Rode, JuliaKönig, JuliaHutchinson, AshleyThunberg, PerPersson, JonasBrummer, Robert Jan

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