To Örebro University

oru.seÖrebro University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Nanocellulose composite wound dressings for real-time pH wound monitoring
Laboratory of Molecular Materials, Division of Biophysics and Bioengineering, Department of Physics, Chemistry and Biology, Linköping University, SE-581 83, Linköping, Sweden.
Laboratory of Molecular Materials, Division of Biophysics and Bioengineering, Department of Physics, Chemistry and Biology, Linköping University, SE-581 83, Linköping, Sweden.
Division of Materials Science, Department of Engineering Sciences and Mathematics, Luleå University of Technology, SE-971 87, Luleå, Sweden.
Division of Materials Science, Department of Engineering Sciences and Mathematics, Luleå University of Technology, SE-971 87, Luleå, Sweden.
Show others and affiliations
2023 (English)In: Materials today. Bio, E-ISSN 2590-0064, Vol. 19, article id 100574Article in journal (Refereed) Published
Abstract [en]

The skin is the largest organ of the human body. Wounds disrupt the functions of the skin and can have catastrophic consequences for an individual resulting in significant morbidity and mortality. Wound infections are common and can substantially delay healing and can result in non-healing wounds and sepsis. Early diagnosis and treatment of infection reduce risk of complications and support wound healing. Methods for monitoring of wound pH can facilitate early detection of infection. Here we show a novel strategy for integrating pH sensing capabilities in state-of-the-art hydrogel-based wound dressings fabricated from bacterial nanocellulose (BC). A high surface area material was developed by self-assembly of mesoporous silica nanoparticles (MSNs) in BC. By encapsulating a pH-responsive dye in the MSNs, wound dressings for continuous pH sensing with spatiotemporal resolution were developed. The pH responsive BC-based nanocomposites demonstrated excellent wound dressing properties, with respect to conformability, mechanical properties, and water vapor transmission rate. In addition to facilitating rapid colorimetric assessment of wound pH, this strategy for generating functional BC-MSN nanocomposites can be further be adapted for encapsulation and release of bioactive compounds for treatment of hard-to-heal wounds, enabling development of novel wound care materials.

Place, publisher, year, edition, pages
Elsevier, 2023. Vol. 19, article id 100574
Keywords [en]
Bacterial nanocellulose, Infection, Mesoporous silica nanoparticles, Wound dressing, pH sensor
National Category
Biomaterials Science
Identifiers
URN: urn:nbn:se:oru:diva-104577DOI: 10.1016/j.mtbio.2023.100574ISI: 000944392500001PubMedID: 36852226Scopus ID: 2-s2.0-85148095686OAI: oai:DiVA.org:oru-104577DiVA, id: diva2:1740579
Funder
Swedish Foundation for Strategic Research, FFL15-0026 RMX18-0039Vinnova, 2016-05156Knut and Alice Wallenberg Foundation, 2016.0231Swedish Research Council, 2021-04427
Note

Funding agencies:

Swedish Government Strategic Research Area in Materials Science on Functional Materials at Linköping University 2009-00971

Swedish strategic research program Bio4Energy

Available from: 2023-03-01 Created: 2023-03-01 Last updated: 2024-11-11Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records

Wiman, EmanuelKhalaf, HazemBengtsson, Torbjörn

Search in DiVA

By author/editor
Wiman, EmanuelKhalaf, HazemBengtsson, Torbjörn
By organisation
School of Medical Sciences
Biomaterials Science

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 30 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf