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Potential Modulation of Inflammation and Physical Function by Combined Probiotics, Omega-3 Supplementation and Vitamin D Supplementation in Overweight/Obese Patients with Chronic Low-Grade Inflammation: A Randomized, Placebo-Controlled Trial
Department of Nutritional Medicine and Prevention, University of Hohenheim, Stuttgart, Germany.
Department of Nutritional Medicine and Prevention, University of Hohenheim, Stuttgart, Germany.
Örebro University, School of Medical Sciences. Nutrition-Gut-Brain Interactions Research Centre, School of Medical Sciences, Örebro University, Örebro, Sweden; Food and Health Programme, Örebro University, Örebro, Sweden, Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.ORCID iD: 0000-0002-7678-5954
Örebro University, School of Medical Sciences. Nutrition-Gut-Brain Interactions Research Centre.
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2023 (English)In: International Journal of Molecular Sciences, ISSN 1661-6596, E-ISSN 1422-0067, Vol. 24, no 10, article id 8567Article in journal (Refereed) Published
Abstract [en]

Obesity is characterized by low-grade inflammation and increased gut permeability. Here, we aim to evaluate the effect of a nutritional supplement on these parameters in subjects with overweight and obesity. A double-blinded, randomized clinical trial was conducted in 76 adults with overweight or obesity (BMI 28 to 40) and low-grade inflammation (high-sensitivity C-reactive protein (hs-CRP) between 2 and 10 mg/L). The intervention consisted of a daily intake of a multi-strain probiotic of Lactobacillus and Bifidobacterium, 640 mg of omega-3 fatty acids (n-3 FAs), and 200 IU of vitamin D (n = 37) or placebo (n = 39), administered for 8 weeks. hs-CRP levels did not change post-intervention, other than an unexpected slight increase observed in the treatment group. Interleukin (IL)-6 levels decreased in the treatment group (p = 0.018). The plasma fatty acid (FA) levels of the arachidonic acid (AA)/eicosapentaenoic acid (EPA) ratio and n-6/n-3 ratio (p < 0.001) decreased, and physical function and mobility improved in the treatment group (p = 0.006). The results suggest that hs-CRP may not be the most useful inflammatory marker, but probiotics, n-3 FAs, and vitamin D, as non-pharmaceutical supplements, may exert modest effects on inflammation, plasma FA levels, and physical function in patients with overweight and obesity and associated low-grade inflammation.

Place, publisher, year, edition, pages
MDPI , 2023. Vol. 24, no 10, article id 8567
Keywords [en]
obesity, overweight, chronic low-grade inflammation, probiotics, omega-3 fatty acids, hs-CRP
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:oru:diva-106323DOI: 10.3390/ijms24108567ISI: 000997365800001PubMedID: 37239916Scopus ID: 2-s2.0-85160373404OAI: oai:DiVA.org:oru-106323DiVA, id: diva2:1770260
Note

Funding agency:

Pfizer Consumer Healthcare

Available from: 2023-06-19 Created: 2023-06-19 Last updated: 2023-06-19Bibliographically approved

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Tingö, LinaHutchinson, Ashley N.Brummer, Robert J.

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