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Glimepiride Compared to Liraglutide Increases Plasma Levels of miR-206, miR-182-5p, and miR-766-3p in Type 2 Diabetes Mellitus: A Randomized Controlled Trial
Örebro University, School of Science and Technology. (Life Science Center)ORCID iD: 0000-0001-9713-2365
Örebro University, School of Medical Sciences. Department of Clinical Research Laboratory, Inflammatory Response and Infection Susceptibility Center (iRiSC), Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, Stockholm, Sweden.ORCID iD: 0000-0003-1785-8540
School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Örebro University, School of Medical Sciences.ORCID iD: 0000-0003-1025-1682
2023 (English)In: Diabetes & metabolism journal, ISSN 2233-6079, E-ISSN 2233-6087, Vol. 47, no 5, p. 668-681Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Diabetes is a chronic disease with several long-term complications. Several glucose-lowering drugs are used to treat type 2 diabetes mellitus (T2DM), e.g., glimepiride and liraglutide, in which both having different modes of action. Circulating microRNAs (miRNAs) are suggested as potential biomarkers that are associated with the disease development and the effects of the treatment. In the current study we evaluated the effect of glimepiride, liraglutide on the expression of the circulating miRNAs.

METHODS: The present study is a post hoc trial from a previously randomized control trial comparing liraglutide versus glimepiride both in combination with metformin in subjects with T2DM, and subclinical heart failure. miRNAs were determined in the subjects' serum samples with next generation sequencing. Expression patterns of the circulating miRNAs were analyzed using bioinformatic univariate and multivariate analyses (clinical trial registration: NCT01425580).

RESULTS: Univariate analyses show that treatment with glimepiride altered expression of three miRNAs in patient serum, miR-206, miR-182-5p, and miR-766-3p. Both miR-182-5p and miR-766-3p were also picked up among the top contributing miRNAs with penalized regularised logistic regressions (Lasso). The highest-ranked miRNAs with respect to Lasso coefficients were miR-3960, miR-31-5p, miR-3613-3p, and miR-378a-3p. Liraglutide treatment did not significantly influence levels of circulating miRNAs.

CONCLUSION: Present study indicates that glucose-lowering drugs differently affect the expression of circulating miRNAs in serum in individuals with T2DM. More studies are required to investigate possible mechanisms by which glimepiride is affecting the expression of circulating miRNAs.

Place, publisher, year, edition, pages
Korean Diabetes Association , 2023. Vol. 47, no 5, p. 668-681
Keywords [en]
Circulating microRNA, Diabetes mellitus, type 2, Glimepiride, Liraglutide
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:oru:diva-106587DOI: 10.4093/dmj.2022.0342ISI: 001151423000006PubMedID: 37349083Scopus ID: 2-s2.0-85174408868OAI: oai:DiVA.org:oru-106587DiVA, id: diva2:1775756
Funder
Novo NordiskAvailable from: 2023-06-27 Created: 2023-06-27 Last updated: 2024-02-14Bibliographically approved

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Scherbak, Nikolai N.Kruse, RobertJendle, Johan

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