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Limosilactobacillus reuteri DSM 17938 supplementation and SARS-CoV-2 specific antibody response in healthy adults: a randomized, triple-blinded, placebo-controlled trial
Örebro University, School of Medical Sciences. Nutrition-Gut-Brain Interactions Research Centre, School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.ORCID iD: 0000-0002-1905-918x
Örebro University, School of Medical Sciences. Nutrition-Gut-Brain Interactions Research Centre, School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.ORCID iD: 0000-0001-9402-4756
Örebro University, School of Health Sciences. Nutrition-Gut-Brain Interactions Research Centre, School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.ORCID iD: 0000-0001-6061-4643
Örebro University, School of Medical Sciences. Nutrition-Gut-Brain Interactions Research Centre, School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
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2023 (English)In: Gut microbes, ISSN 1949-0976, E-ISSN 1949-0984, Vol. 15, no 1, article id 2229938Article in journal (Refereed) Published
Abstract [en]

Studies have shown that probiotics can decrease the symptoms of respiratory tract infections as well as increase antibody responses following certain vaccinations. We examined the effect of probiotic supplementation on anti-SARS-CoV-2 specific antibody responses upon SARS-CoV-2 infection as well as after COVID-19 vaccination. In this randomized, triple-blinded, placebo-controlled intervention study with a parallel design, 159 healthy adults without prior SARS-CoV-2 infection or COVID-19 vaccination and any known risk factors for severe COVID-19 were randomly allocated into two study arms. The active treatment arm consumed a probiotic product containing a minimum of 1 × 108 colony-forming units of Limosilactobacillus reuteri DSM 17938 + 10 μg vitamin D3 twice daily for 6 months. The placebo arm consumed identical tablets containing only 10 μg vitamin D3. Anti-SARS-CoV-2 specific antibodies and virus neutralizing antibody titers were analyzed from blood samples collected at baseline, after 3 months, and after 6 months. Differences in serum antibody titers between the two study arms were tested with independent t-test using log-transformed values. In the intention-to-treat (ITT) analysis, SARS-CoV-2 infected individuals in the active treatment arm (n = 6) tended to have higher serum anti-spike IgG (609 [168-1480] BAU/ml vs 111 [36.1-1210] BAU/ml, p = 0.080) and anti-receptor binding domain (RBD) IgG (928 [212-3449] BAU/ml vs (83.7 [22.8-2094] BAU/ml, p = 0.066) levels than individuals in the placebo arm (n = 6). Considering individuals who were fully vaccinated with mRNA-based COVID-19 vaccines, the active treatment arm (n = 10) exhibited significantly higher serum levels of anti-RBD IgA (135 [32.9-976] BAU/ml vs 61.3 [26.7-97.1] BAU/ml, p = 0.036) than the placebo arm (n = 7) >28 days postvaccination. Supplementation with specific probiotics might improve the long-term efficacy of mRNA-based COVID-19 vaccines via enhanced IgA response.

Place, publisher, year, edition, pages
Taylor & Francis, 2023. Vol. 15, no 1, article id 2229938
Keywords [en]
COVID-19, Probiotics, SARS-CoV-2, antibody, immunology
National Category
Infectious Medicine
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URN: urn:nbn:se:oru:diva-106943DOI: 10.1080/19490976.2023.2229938ISI: 001020016900001PubMedID: 37401761Scopus ID: 2-s2.0-85164011823OAI: oai:DiVA.org:oru-106943DiVA, id: diva2:1779922
Available from: 2023-07-05 Created: 2023-07-05 Last updated: 2023-08-01Bibliographically approved

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Forsgård, Richard A.Rode, JuliaLobenius Palmér, KarinKamm, AnnalenaPatil, SnehalLentjes, Marleen A. H.Montgomery, ScottBrummer, Robert Jan

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