This paper investigates the potential tensions that may arise between technology-neutral innovation policy and the advancement of sustainability-related objectives, specifically in the context of road freight transport. Despite the availability of zero-emission vehicles (ZEVs) and regulatory actions, widespread adoption of ZEVs among transport operators has been slow. To shed light on potential reasons for this, the paper examines the relationship between perceived technology neutrality of existing policies, contestations over future technological pathways, and anticipated regret on innovation adoption intentions of transport operators with a survey. The findings suggest that technology-neutral policies may contribute to increased uncertainties over future technology pathways and anticipated regret over adoption decisions which may make transport operators hesitant to invest in already available ZEVs. The paper contributes, therefore, to innovation policy development by high-lighting the need to reconsider the principle of technological neutrality and calls for caution when implementing such policies, as it underscores the importance of considering sector-specific challenges and uncertainties when designing effective sustainability-oriented innovation policies.