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Atrial fibrillation increases the risk of all-cause dementia, Alzheimer's disease, and vascular dementia: A cohort study of 373, 415 participants in the UK Biobank
Clinical Research Unit, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Clinical Research Unit, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China; Department of Medical Service, Naval Hospital of Eastern theater, Zhoushan, Zhejiang 316000, China.
Department of Health Management, Naval Medical University, Shanghai 200433, China.
Department of Health Statistics, Naval Medical University, Shanghai 200433, China.
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2024 (English)In: Journal of Affective Disorders, ISSN 0165-0327, E-ISSN 1573-2517, Vol. 351, p. 323-330Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Accumulated evidence has highlighted the association between atrial fibrillation and the risk of developing dementia.

METHODS: This current cohort study utilized data from the UK Biobank to explore the association between atrial fibrillation (AF) and all-cause dementia (ACD), encompassing its main subtypes (Alzheimer's disease (AD), and vascular dementia (VD)). Cox proportional hazards models were applied to examine the association of AF and dementia with its primary subtypes after adjusting for different sets of covariates. Hazard ratios (HRs) with 95 % confidential intervals (CIs) were estimated to quantify the associated risks. Competing risk model was applied in sensitivity analysis.

RESULTS: After exclusion, 373, 415 participants entered the primary analysis. Among these, 27, 934 (7.48 %) were with a history AF at baseline, while 345, 481 (92.52 %) were without. During a mean follow-up of 13.45 years, ACD was diagnosed in 1215 individuals with AF and 3988 individuals without AF. Participants with AF had higher risks of ACD (1.79 [1.67-1.91]), AD (1.48 [1.32-1.65]), and VD (2.46 [2.17-2.80]) in the fully adjusted Cox regression models. Results of subgroup and sensitivity analyses predominantly aligned with the positive associations in primary analysis.

LIMITATIONS: The applicability of our findings to diverse ethnicities might require careful consideration and the behind biological mechanisms need to be further revealed.

CONCLUSIONS: It indicated that people with atrial fibrillation had an increased future risk of all-cause dementia, Alzheimer's disease, vascular dementia. Atrial fibrillation screening and prevention strategies should take into account to prevent and delay the onset of dementia.

Place, publisher, year, edition, pages
Elsevier, 2024. Vol. 351, p. 323-330
Keywords [en]
All-cause dementia, Alzheimer's disease, Atrial fibrillation, Cohort study, UK Biobank, Vascular dementia
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:oru:diva-111232DOI: 10.1016/j.jad.2024.01.224ISI: 001177216300001PubMedID: 38286227Scopus ID: 2-s2.0-85184052899OAI: oai:DiVA.org:oru-111232DiVA, id: diva2:1833656
Note

This study was supported by the following funding: The 2021 Shanghai “Science and Technology Innovation Action Plan” (Project Number: 21XD1432900), the Research Project Plan of the Shanghai Municipal Health Commission (Project Number: 202150019), the Project of Hospital Management from Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine (Project Number: YGA202308), and the 2022 Medical and Health Science and Technology Plan of Zhoushan City, China (Project Number: 2022JYB05).

Available from: 2024-02-01 Created: 2024-02-01 Last updated: 2024-03-20Bibliographically approved

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