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Anxiety, depression and quality of life in relation to SARS-CoV-2 antibodies in individuals living with diabetes during the second wave of COVID-19
Department of Clinical Sciences Malmö, Lund University, Sweden.
Örebro University, School of Medical Sciences. Örebro University Hospital. Clinical Epidemiology and Biostatistics, School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Unit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0002-3552-9153
Örebro University, School of Behavioural, Social and Legal Sciences. School of Behavioural, Social and Legal Sciences, Center for Health and Medical Psychology, Örebro University, Sweden; Department of Behavioural Sciences and Learning, Linköping University, Linköping, Sweden.ORCID iD: 0000-0002-9736-8228
Örebro University, School of Medical Sciences. Örebro University Hospital. Center for Clinical Research Dalarna, Uppsala University, Falun, Sweden; Vansbro Primary Health Care Center, Vansbro, Sweden.ORCID iD: 0000-0002-3671-5046
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2024 (English)In: Diabetes epidemiology and management, ISSN 2666-9706, Vol. 13, article id 100194Article in journal (Refereed) Published
Abstract [en]

Aims: The objective was to compare anxiety, depression, and quality of life (QoL) in individuals living with type 1 (T1D) and type 2 (T2D) diabetes with matched controls during the second wave of the COVID-19 pandemic.

Methods: Via randomization, individuals living with diabetes T1D (n = 203) and T2D (n = 413), were identified during February-July 2021 through health-care registers. Population controls (n = 282) were matched for age, gender, and residential area. Questionnaires included self-assessment of anxiety, depression, QoL, and demographics in relation to SARS-CoV-2 exposure. Blood was collected through home-capillary sampling, and SARS-CoV-2 Nucleocapsid (NCP) and Spike antibodies (SC2_S1) were determined by multiplex Antibody Detection by Agglutination-PCR (ADAP) assays.

Results: Younger age and health issues were related to anxiety, depression, and QoL, with no differences between the study groups. Female gender was associated with anxiety, while obesity was associated with lower QoL. The SARS-CoV-2 NCP seroprevalence was higher in T1D (8.9 %) compared to T2D (3.9 %) and controls (4.0 %), while the SARS-CoV-2 SC2_S1 seroprevalence was higher for controls (25.5 %) compared to T1D (16.8 %) and T2D (14.0 %).

Conclusions: A higher SARS-CoV-2 infection rate in T1D may be explained by younger age and higher employment rate, and the associated increased risk for viral exposure.

Place, publisher, year, edition, pages
Elsevier, 2024. Vol. 13, article id 100194
Keywords [en]
Diabetes, SARS-CoV-2, COVID-19, Anxiety, Depression, Quality of life, Virus antibodies
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:oru:diva-111559DOI: 10.1016/j.deman.2023.100194ISI: 001154927400001PubMedID: 38463606Scopus ID: 2-s2.0-85182889973OAI: oai:DiVA.org:oru-111559DiVA, id: diva2:1837670
Funder
Swedish Foundation for Strategic Research, IRC15-0067
Note

This work was supported by NIH SBIR 2R44DK110005-02, Strategic Research Area Exodiab Dnr 2009-1039, and the Swedish Foundation for Strategic Research Dnr IRC15-0067.

Available from: 2024-02-14 Created: 2024-02-14 Last updated: 2024-03-19Bibliographically approved

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Cao, YangHesser, HugoHårdstedt, MariaJansson, Stefan P. O.Sundqvist, MartinTevell, StaffanWahlberg, JeanetteJendle, Johan

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Endocrinology and Diabetes

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