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The impact of kidney function on plasma neurofilament light and phospho-tau 181 in a community-based cohort: the Shanghai Aging Study
Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China; National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China; National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China; Departemnt of Nephrology, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China; National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
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2024 (English)In: Alzheimer's Research & Therapy, E-ISSN 1758-9193, Vol. 16, no 1, article id 32Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The blood-based biomarkers are approaching the clinical practice of Alzheimer's disease (AD). Chronic kidney disease (CKD) has a potential confounding effect on peripheral protein levels. It is essential to characterize the impact of renal function on AD markers.

METHODS: Plasma phospho-tau181 (P-tau181), and neurofilament light (NfL) were assayed via the Simoa HD-X platform in 1189 dementia-free participants from the Shanghai Aging Study (SAS). The estimated glomerular filter rate (eGFR) was calculated. The association between renal function and blood NfL, P-tau181 was analyzed. An analysis of interactions between various demographic and comorbid factors and eGFR was conducted.

RESULTS: The eGFR levels were negatively associated with plasma concentrations of NfL and P-tau181 (B = - 0.19, 95% CI - 0.224 to - 0.156, P < 0.001; B = - 0.009, 95% CI - 0.013 to -0.005, P < 0.001, respectively). After adjusting for demographic characteristics and comorbid diseases, eGFR remained significantly correlated with plasma NfL (B = - 0.010, 95% CI - 0.133 to - 0.068, P < 0.001), but not with P-tau181 (B = - 0.003, 95% CI - 0.007 to 0.001, P = 0.194). A significant interaction between age and eGFR was found for plasma NfL (Pinteraction < 0.001). In participants ≥ 70 years and with eGFR < 60 ml/min/1.73 m2, the correlation between eGFR and plasma NfL was significantly remarkable (B = - 0.790, 95% CI - 1.026 to - 0,554, P < 0.001).

CONCLUSIONS: Considering renal function and age is crucial when interpreting AD biomarkers in the general aging population.

Place, publisher, year, edition, pages
BioMed Central (BMC), 2024. Vol. 16, no 1, article id 32
Keywords [en]
Comorbid conditions, Glomerular filter rate, Neurofilament light, Phospho-tau181, Renal function
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:oru:diva-111662DOI: 10.1186/s13195-024-01401-2ISI: 001161492500001PubMedID: 38347655OAI: oai:DiVA.org:oru-111662DiVA, id: diva2:1839486
Note

This work was supported by grants from the National Natural Science Foundation of China (82371429, 82071200, 82173599), National Ministry of Science and Technology (SQ2021AAA010157), Shanghai Municipal Science and Technology Major Project (2018SHZDZX01 and ZJ LAB).

Available from: 2024-02-21 Created: 2024-02-21 Last updated: 2024-02-26Bibliographically approved

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