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Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease
Örebro University, School of Medical Sciences.ORCID iD: 0000-0001-5752-4196
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway.
Örebro University, School of Medical Sciences. Department of Clinical Research Laboratory, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.ORCID iD: 0000-0003-1785-8540
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2024 (English)In: Nature Communications, E-ISSN 2041-1723, Vol. 15, no 1, article id 4567Article in journal (Refereed) Published
Abstract [en]

Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-naïve pediatric patients and validating findings in an independent inception cohort. The lipidomic signature comprising of only lactosyl ceramide (d18:1/16:0) and phosphatidylcholine (18:0p/22:6) improves the diagnostic prediction compared with high-sensitivity C-reactive protein. Adding high-sensitivity C-reactive protein to the signature does not improve its performance. In patients providing a stool sample, the diagnostic performance of the lipidomic signature and fecal calprotectin, a marker of gastrointestinal inflammation, does not substantially differ. Upon investigation in a third pediatric cohort, the findings of increased lactosyl ceramide (d18:1/16:0) and decreased phosphatidylcholine (18:0p/22:6) absolute concentrations are confirmed. Translation of the lipidomic signature into a scalable diagnostic blood test for pediatric inflammatory bowel disease has the potential to support clinical decision making.

Place, publisher, year, edition, pages
Springer Nature, 2024. Vol. 15, no 1, article id 4567
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:oru:diva-114075DOI: 10.1038/s41467-024-48763-7ISI: 001238270100028PubMedID: 38830848Scopus ID: 2-s2.0-85195011168OAI: oai:DiVA.org:oru-114075DiVA, id: diva2:1865705
Funder
Örebro UniversitySwedish Foundation for Strategic Research, RB13-0160Swedish Research Council, 2020-02021NordForsk, 90569
Note

This work was supported by the Swedish Foundation for Strategic Research [RB13-0160 to J.H.], the Swedish Research Council [2020-02021 to J.H.], the Örebro University Hospital research foundation [OLL-890291 to J.H.], NordForsk [90569 to J.H.]. 

Available from: 2024-06-05 Created: 2024-06-05 Last updated: 2024-07-23Bibliographically approved

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Salihovic, SamiraKruse, RobertBazov, IgorOresic, MatejLindqvist, Carl MårtenRepsilber, DirkHyötyläinen, TuuliaHalfvarson, Jonas

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