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Exploring the circulating metabolome of sepsis: metabolomic and lipidomic profiles sampled in the ambulance
Örebro University, School of Medical Sciences. (Inflammatory Response and Infection Susceptibility Centre (iRiSC))ORCID iD: 0000-0001-5752-4196
Örebro University, School of Medical Sciences. (Inflammatory Response and Infection Susceptibility Centre (iRiSC))ORCID iD: 0000-0002-6045-4800
Örebro University, School of Medical Sciences. (Inflammatory Response and Infection Susceptibility Centre (iRiSC))ORCID iD: 0000-0003-1785-8540
Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden.
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2024 (English)In: Metabolomics, ISSN 1573-3882, E-ISSN 1573-3890, Vol. 20, no 5, article id 111Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Sepsis is defined as a dysfunctional host response to infection. The diverse clinical presentations of sepsis pose diagnostic challenges and there is a demand for enhanced diagnostic markers for sepsis as well as an understanding of the underlying pathological mechanisms involved in sepsis. From this perspective, metabolomics has emerged as a potentially valuable tool for aiding in the early identification of sepsis that could highlight key metabolic pathways and underlying pathological mechanisms.

OBJECTIVE: The aim of this investigation is to explore the early metabolomic and lipidomic profiles in a prospective cohort where plasma samples (n = 138) were obtained during ambulance transport among patients with infection according to clinical judgement who subsequently developed sepsis, patients who developed non-septic infection, and symptomatic controls without an infection.

METHODS: Multiplatform metabolomics and lipidomics were performed using UHPLC-MS/MS and UHPLC-QTOFMS. Uni- and multivariable analysis were used to identify metabolite profiles in sepsis vs symptomatic control and sepsis vs non-septic infection.

RESULTS: Univariable analysis disclosed that out of the 457 annotated metabolites measured across three different platforms, 23 polar, 27 semipolar metabolites and 133 molecular lipids exhibited significant differences between patients who developed sepsis and symptomatic controls following correction for multiple testing. Furthermore, 84 metabolites remained significantly different between sepsis and symptomatic controls following adjustment for age, sex, and Charlson comorbidity score. Notably, no significant differences were identified in metabolites levels when comparing patients with sepsis and non-septic infection in univariable and multivariable analyses.

CONCLUSION: Overall, we found that the metabolome, including the lipidome, was decreased in patients experiencing infection and sepsis, with no significant differences between the two conditions. This finding indicates that the observed metabolic profiles are shared between both infection and sepsis, rather than being exclusive to sepsis alone.

Place, publisher, year, edition, pages
Springer, 2024. Vol. 20, no 5, article id 111
Keywords [en]
Ambulance, Infection, Lipidomics, Metabolomics, Plasma, Sepsis
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:oru:diva-116549DOI: 10.1007/s11306-024-02172-5ISI: 001326446300002PubMedID: 39369060Scopus ID: 2-s2.0-85205758484OAI: oai:DiVA.org:oru-116549DiVA, id: diva2:1903728
Funder
Örebro UniversityNyckelfondenRegion Örebro County, OLL-986200Region Örebro County, OLL298Region Örebro County, 972724Region Örebro County, OLL-960082Region Örebro County, OLL-935301Region Örebro County, OLL-880411Knowledge Foundation, 2016-0044Knowledge Foundation, 2018-0133Knowledge Foundation, 2020-0017Knowledge Foundation, 2020-0257Available from: 2024-10-07 Created: 2024-10-07 Last updated: 2024-10-18Bibliographically approved

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Salihovic, SamiraEklund, DanielKruse, RobertHyötyläinen, TuuliaSärndahl, EvaKurland, Lisa

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