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Associations between lactase persistence and the metabolic syndrome in a cross-sectional study in the Canary Islands
Örebro universitet, Institutionen för klinisk medicin. (AFC)
Univ Las Palmas Gran Canaria, Fac Hlth Sci, Dept Clin Sci, Canary Isl, Spain; Hosp Insular Gran Canaria, Canarian Hlth Serv, Serv Prevent Med, Canary Isl, Spain.
Örebro universitet, Institutionen för klinisk medicin. (AFC)ORCID-id: 0000-0001-8828-9299
Univ Las Palmas Gran Canaria, Fac Hlth Sci, Dept Clin Sci, Canary Isl, Spain; Hosp Insular Gran Canaria, Canarian Hlth Serv, Serv Prevent Med, Canary Isl, Spain.
Vise andre og tillknytning
2009 (engelsk)Inngår i: European Journal of Nutrition, ISSN 1436-6207, E-ISSN 1436-6215, Vol. 49, nr 3, s. 141-146Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: The single nucleotide polymorphism (SNP) LCT -13910 C>T, associated with genetically determined phenotypes of lactase persistence (LP) or non-persistence (LNP), was studied in relation to the metabolic syndrome (MS).

AIim of the study: The aim was to determine if milk intake and MS are associated. We applied Mendelian randomization (MR). The SNP, LCT -13910 C>T, with the genotypes LP (TT/CT) and LNP (CC), was taken as a proxy for milk consumption.

Methods: A representative sample of adults belonging to the Canary Islands Nutrition Survey (ENCA) in Spain aged 18-75 years (n = 551) was genotyped for the LCT -13910 C>T polymorphism. We used the International Diabetes Federation (IDF) criteria to define MS. RESULTS: 60% of the population was LP and 40% LNP. One hundred seven LP subjects (35.0%) and 53 LNP subjects (25.6%) showed MS (chi (2) = 5.04, p = 0.025). LP subjects showed a significantly higher odds ratio (OR) for MS than LNP subjects computed for the whole population: both the crude OR (1.56; 95% CI 1.06-2.31) and adjusted OR for sex, age, daily energy intake, physical activity and educational level (1.57; 95% CI 1.02-2.43). Adjusted OR for women with LP was 1.93; 95% CI 1.06-3.52.

Conclusions: The T allele of the SNP might constitute a nutrigenetic factor increasing the susceptibility of LP subjects, especially women, to develop MS in the Canary Islands.

sted, utgiver, år, opplag, sider
Heidelberg, Germany: Springer, 2009. Vol. 49, nr 3, s. 141-146
Emneord [en]
LCT-13910 C > T polymorphism, Metabolic syndrome, Metabolic syndrome, Milk, Mendelian randomization
HSV kategori
Forskningsprogram
Näringslära
Identifikatorer
URN: urn:nbn:se:oru:diva-9716DOI: 10.1007/s00394-009-0058-2ISI: 000275631500002PubMedID: 19844753Scopus ID: 2-s2.0-77950864600OAI: oai:DiVA.org:oru-9716DiVA, id: diva2:293576
Tilgjengelig fra: 2010-02-12 Laget: 2010-02-12 Sist oppdatert: 2018-01-12bibliografisk kontrollert
Inngår i avhandling
1. Lactase Persistence and Lactase Non-Persistence: Prevalence, influence on body fat, body height, and relation to the metabolic syndrome
Åpne denne publikasjonen i ny fane eller vindu >>Lactase Persistence and Lactase Non-Persistence: Prevalence, influence on body fat, body height, and relation to the metabolic syndrome
2010 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
sted, utgiver, år, opplag, sider
Örebro: Örebro universitet, 2010. s. 45
Serie
Örebro Studies in Medicine, ISSN 1652-4063 ; 48
HSV kategori
Forskningsprogram
Medicin
Identifikatorer
urn:nbn:se:oru:diva-11854 (URN)978-91-7668-767-3 (ISBN)
Disputas
2010-12-15, Wilandersalen, Universitetssjukhuset Örebro, Fakultetsgatan 1, 701 82 Örebro, 09:00
Opponent
Veileder
Tilgjengelig fra: 2010-09-17 Laget: 2010-09-17 Sist oppdatert: 2017-10-17bibliografisk kontrollert

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