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Prevalence and trends in adult-type hypolactasia in different age cohorts in Central Sweden diagnosed by genotyping for the adult-type hypolactasia-linked LCT -13910C > T mutation
Örebro universitet, Hälsoakademin.
Örebro universitet, Hälsoakademin.ORCID-id: 0000-0001-8828-9299
Örebro universitet, Hälsoakademin.
Vise andre og tillknytning
2007 (engelsk)Inngår i: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, E-ISSN 1502-7708, Vol. 42, nr 2, s. 165-170Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

OBJECTIVE: Adult-type hypolactasia (AtH) can be diagnosed by genotyping in addition to functional tests or intestinal biopsy. The aims of this study were to estimate the prevalence of AtH by genotyping and to investigate whether AtH prevalence has changed in Sweden during the 20th century. MATERIAL AND METHODS: Schoolchildren (n=690) born in 1983 and 1989, and elderly individuals (n=392) born between 1920 and 1932 were genotyped for AtH using Pyrosequencing technology. RESULTS: The overall prevalence of AtH among children was 14.1%. The majority of children (92%, n=635) were Caucasians with genotype prevalences: CC, 61 (10%); CT, 259 (41%); TT, 307 (49%). The frequency of the mutated allele q was 0.300 in this cohort. The prevalence of AtH estimated from the Hardy-Weinberg equilibrium (HWE) (q 2), was 9.0% (95% CI: 6.7-11.2%). Eight percent (n=55) of the children were non-Caucasian; genotype prevalences were CC, 36 (66%); CT, 15 (27%); TT, 4 (7%). The prevalence of AtH in these children estimated from HWE was 62.5% (95% CI: 49.7-75.3%). The elderly subjects were all Caucasians. Their genotype prevalences were: CC, 20 (5%); CT, 166 (42%); TT, 206 (53%); the frequency of the mutated allele q was 0.262 and their AtH prevalence estimated from HWE was 6.8% (95% CI: 4.3-9.2%). CONCLUSIONS: The overall prevalence of AtH in children (14%) was higher than previously thought. Among Caucasians, higher figures were seen in children than in the elderly (9% versus 6.8%). The prevalence thus seems to be increasing and this may be due to the immigration of both non-Caucasian and Caucasian groups with a higher prevalence of AtH.

sted, utgiver, år, opplag, sider
Oslo: Taylor & Francis , 2007. Vol. 42, nr 2, s. 165-170
HSV kategori
Forskningsprogram
medicin
Identifikatorer
URN: urn:nbn:se:oru:diva-11542DOI: 10.1080/00365520600825257PubMedID: 17327935OAI: oai:DiVA.org:oru-11542DiVA, id: diva2:342910
Tilgjengelig fra: 2010-08-11 Laget: 2010-08-11 Sist oppdatert: 2017-12-12bibliografisk kontrollert
Inngår i avhandling
1. Lactase Persistence and Lactase Non-Persistence: Prevalence, influence on body fat, body height, and relation to the metabolic syndrome
Åpne denne publikasjonen i ny fane eller vindu >>Lactase Persistence and Lactase Non-Persistence: Prevalence, influence on body fat, body height, and relation to the metabolic syndrome
2010 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
sted, utgiver, år, opplag, sider
Örebro: Örebro universitet, 2010. s. 45
Serie
Örebro Studies in Medicine, ISSN 1652-4063 ; 48
HSV kategori
Forskningsprogram
Medicin
Identifikatorer
urn:nbn:se:oru:diva-11854 (URN)978-91-7668-767-3 (ISBN)
Disputas
2010-12-15, Wilandersalen, Universitetssjukhuset Örebro, Fakultetsgatan 1, 701 82 Örebro, 09:00
Opponent
Veileder
Tilgjengelig fra: 2010-09-17 Laget: 2010-09-17 Sist oppdatert: 2017-10-17bibliografisk kontrollert

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