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Impaired activation of IFN-gamma+CD4+ T cells in peripheral blood of patients with dilated cardiomyopathy
Sahlgrenska Acad, Univ Gothenburg, Gothenburg, Sweden.
Sahlgrenska Acad, Univ Gothenburg, Gothenburg, Sweden.
Örebro University, School of Health and Medical Sciences.ORCID iD: 0000-0001-5460-8888
Sahlgrenska Acad, Univ Gothenburg, Gothenburg, Sweden.
2010 (English)In: Cellular Immunology, ISSN 0008-8749, E-ISSN 1090-2163, Vol. 263, no 2, p. 224-229Article in journal (Refereed) Published
Abstract [en]

Viral persistence and autoantibodies are pathogenic components in patients with idiopathic dilated cardiomyopathy (DCM). The aim was to evaluate T-cell function in DCM using different flow cytometry based detection techniques. Following stimulation, the frequency of IFN-gamma-producing CD4+ T cells was significantly lower in patients compared with controls. In contrast, the frequency of IL-4 producing CD4+ T cells was no different. In supernatants of cultured PBMC, IFN-gamma and IL-10 were significantly lower in patients. In addition, lymphocyte proliferation was significantly lower in patients compared with controls, whereas major lymphocyte subsets were not different. IFN-gamma and IL-10 are key cytokines in the ability to mount protective immune responses and to maintain self-tolerance. A reduced activation of T-helper 1 (IFN-gamma producing) cells and a decreased capacity to produce IL-10, found in the present study, could explain parts of the autoimmune features seen in patients with DCM.

Place, publisher, year, edition, pages
San Diego, USA: Elsevier, 2010. Vol. 263, no 2, p. 224-229
Keywords [en]
Cardiomyopathy, Patients, Lymphocytes, Interleukins, Flow cytometry
National Category
Medical and Health Sciences Cell Biology Immunology
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-14101DOI: 10.1016/j.cellimm.2010.04.003ISI: 000278666800014PubMedID: 20435301Scopus ID: 2-s2.0-77953359091OAI: oai:DiVA.org:oru-14101DiVA, id: diva2:389780
Available from: 2011-01-20 Created: 2011-01-20 Last updated: 2018-04-23Bibliographically approved

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Hultgren Hörnquist, Elisabeth

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