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Maternal and neonatal outcomes and time trends of gestational diabetes mellitus in Sweden from 1991 to2003
Örebro universitet, Institutionen för hälsovetenskap och medicin.ORCID-id: 0000-0002-2691-7525
Department of Obstetrics and Gynaecology, Örebro University Hospital, Örebro, Sweden.
Statistical and Epidemiology Unit, Örebro University Hospital, Örebro, Sweden.
Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden.
2010 (Engelska)Ingår i: Diabetic Medicine, ISSN 0742-3071, E-ISSN 1464-5491, Vol. 27, nr 4, s. 436-441Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Aims To determine maternal and neonatal outcomes for women with gestational diabetes mellitus (GDM) in Sweden during 1991–2003, and to compare the outcomes in the two time periods.

Methods This is a population-based cohort study using the Swedish Medical Birth Register data for the period 1991–2003. There were 1 260 297 women with singleton pregnancies registered during this time, of whom 10 525 were diagnosed with GDM, based on a 75 g oral glucose tolerance test. The main diagnostic criteria were fasting capillary whole blood glucose ≥ 6.1 mmol⁄l and 2 h blood glucose ≥ 9.0 mmol⁄l.

Results Maternal characteristics differed significantly between the GDM and non-GDM group. Adjusted odds ratios (OR) were as follows: for pre-eclampsia, 1.81 (95% confidence interval (CI) 1.64–2.00); for shoulder dystocia, 2.74 (2.04–3.68); and for Caesarean section, 1.46 (1.38–1.54).No difference was seen in perinatal mortality, stillbirth rates, Apgar scores, fetal distress or transient tachypnoea. There was a markedly higher risk of large for gestational age,OR3.43 (3.21–3.67), and Erb’s palsy, OR 2.56 (1.96–3.32), in the GDMgroup, and statistically significant differences in prematurity < 37 weeks, birthweight > 4.5 kg, and major malformation, OR 1.19–1.71. No statistically significant improvement in outcomes was seen between the two study periods.

Conclusions Women with GDM have higher risks of pre-eclampsia, shoulder dystocia and Caesarean section. Their infants are often large for gestational age and have higher risks of prematurity, Erb’s palsy and major malformations. These outcomes did not improve over time.

Ort, förlag, år, upplaga, sidor
Malden 02148, MA USA: Wiley-Blackwell, 2010. Vol. 27, nr 4, s. 436-441
Nyckelord [en]
gestational diabetes mellitus, maternal outcome, neonatal outcome
Nationell ämneskategori
Medicin och hälsovetenskap Reproduktionsmedicin och gynekologi
Forskningsämne
Medicin
Identifikatorer
URN: urn:nbn:se:oru:diva-21259DOI: 10.1111/j.1464-5491.2010.02978.xISI: 000276466600011OAI: oai:DiVA.org:oru-21259DiVA, id: diva2:482023
Tillgänglig från: 2012-01-23 Skapad: 2012-01-23 Senast uppdaterad: 2019-04-24Bibliografiskt granskad
Ingår i avhandling
1. Gestational diabetes mellitus in Sweden: screening, outcomes, and consequences
Öppna denna publikation i ny flik eller fönster >>Gestational diabetes mellitus in Sweden: screening, outcomes, and consequences
2012 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Ort, förlag, år, upplaga, sidor
Örebro: Örebro universitet, 2012. s. 68
Serie
Örebro Studies in Medicine, ISSN 1652-4063 ; 65
Nyckelord
Gestational diabetes mellitus, fasting blood glucose, screening, neonatal and obstetric outcomes, ethnicity, cardiovascular disease
Nationell ämneskategori
Kirurgi
Forskningsämne
Kirurgi
Identifikatorer
urn:nbn:se:oru:diva-20621 (URN)978-91-7668-847-2 (ISBN)
Disputation
2012-02-17, Wilandersalen, M-huset, Universitetssjukhuset, Örebro, 09:00 (Engelska)
Opponent
Handledare
Tillgänglig från: 2011-12-22 Skapad: 2011-12-22 Senast uppdaterad: 2019-04-24Bibliografiskt granskad

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Fadl, Helena E.

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