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Elution of antitransglutaminase antibodies from duodenal biopsies: a novel approach in the diagnosis of celiac disease
Department of Laboratory Medicine/Microbiology, Örebro University Hospital, Örebro, Sweden.
Örebro universitet, Institutionen för hälsovetenskap och medicin. Division of Gastroenterology, Department of Medicine, Örebro University Hospital, Örebro, Sweden.
Department of Laboratory Medicine/Pathology, Örebro University Hospital, Örebro, Sweden.
Örebro universitet, Institutionen för hälsovetenskap och medicin. Department of Laboratory Medicine/Microbiology, Örebro University Hospital, Örebro, Sweden.
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2012 (Engelska)Ingår i: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 120, nr 8, s. 666-674Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Celiac disease (CeD) is a disease more prevalent and multisymptomatic than was earlier recognized. Whereas prompt initiation of gluten-free diet (GFD) is beneficial in relieving the symptoms, an accurate CeD diagnosis is necessary also to avoid years of restricted diet on uncertain grounds. We propose a new diagnostic method, based on elution of deposited antibodies against transglutaminase (anti-tTG) from duodenal biopsies in patients with symptoms and screening serology analyses suggestive of CeD. The eluates were analyzed in a Phadia 250 fluoroimmunoassay, demonstrating elevated concentrations of anti-tTG in CeD patients, corresponding to serology and histopathology findings. In one case histology was inconclusive, displaying only unspecific inflammation, but eluted anti-tTG was positive. This patient has clinically improved following GFD. We conclude that our novel method represents a new tool in the diagnostic work up in CeD. The detection of deposited anti-tTG at the site of inflammation appears to provide a high sensitivity and specificity using a technique that is quick, simple and reliable. Further studies are needed for optimization and elucidation of suitable applications for this elution method.

Ort, förlag, år, upplaga, sidor
Hoboken, USA: Wiley-Blackwell, 2012. Vol. 120, nr 8, s. 666-674
Nyckelord [en]
Celiac disease, antitransglutaminase antibodies, elution, borderline cases
Nationell ämneskategori
Medicin och hälsovetenskap Immunologi
Forskningsämne
Medicin
Identifikatorer
URN: urn:nbn:se:oru:diva-24221DOI: 10.1111/j.1600-0463.2012.02884.xISI: 000306310500009PubMedID: 22779690Scopus ID: 2-s2.0-84863836943OAI: oai:DiVA.org:oru-24221DiVA, id: diva2:542839
Tillgänglig från: 2012-08-03 Skapad: 2012-08-03 Senast uppdaterad: 2017-12-07Bibliografiskt granskad

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Tysk, CurtHultgren, Olof

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Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)
Medicin och hälsovetenskapImmunologi

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